Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1232270..1232736 Replicon chromosome
Accession NZ_CP011047
Organism Cronobacter sakazakii strain ATCC 29544

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9UG96
Locus tag CSK29544_RS05715 Protein ID WP_007797229.1
Coordinates 1232270..1232545 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V7US84
Locus tag CSK29544_RS05720 Protein ID WP_007899949.1
Coordinates 1232545..1232736 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSK29544_RS05700 1228369..1229211 - 843 WP_007899956.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
CSK29544_RS05705 1229404..1231446 + 2043 WP_007899954.1 oligopeptidase A -
CSK29544_RS05710 1231455..1232207 + 753 WP_007899951.1 16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ -
CSK29544_RS05715 1232270..1232545 - 276 WP_007797229.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSK29544_RS05720 1232545..1232736 - 192 WP_007899949.1 hypothetical protein Antitoxin
CSK29544_RS05725 1232911..1233348 - 438 WP_004388310.1 universal stress protein UspA -
CSK29544_RS05730 1233739..1234074 + 336 WP_007899947.1 universal stress protein UspB -
CSK29544_RS05735 1234125..1235627 - 1503 WP_004388312.1 inorganic phosphate transporter PitA -
CSK29544_RS05740 1235857..1237047 + 1191 WP_007899945.1 NAD(P)/FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10439.03 Da        Isoelectric Point: 5.0362

>T53209 WP_007797229.1 NZ_CP011047:c1232545-1232270 [Cronobacter sakazakii]
MLPIQWTEEAKTDLFALISFVASDNPSAAQALLTRIEESILPAAYYPEMFREGRVPDTREIIAHPNYIVVYKVTSEYLLV
LSVLHARQRYP

Download         Length: 276 bp

>T53209 NZ_CP011047:c1232545-1232270 [Cronobacter sakazakii]
ATGCTCCCCATTCAATGGACTGAAGAAGCAAAAACGGATCTTTTTGCGCTTATTAGTTTTGTTGCCAGTGATAATCCTTC
CGCCGCGCAGGCGCTGTTAACGCGTATTGAAGAATCAATTTTACCCGCAGCGTACTATCCGGAGATGTTCCGCGAAGGCA
GAGTGCCAGATACGCGTGAAATCATTGCTCACCCGAATTACATCGTCGTTTATAAAGTCACTTCTGAATATCTGCTGGTG
CTGAGCGTTCTGCATGCCCGTCAGCGCTACCCCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7130.20 Da        Isoelectric Point: 10.7055

>AT53209 WP_007899949.1 NZ_CP011047:c1232736-1232545 [Cronobacter sakazakii]
MPKHDSPGVSSLNTHKQAEQYKLWFREKVEAAAASRQPITPHDDVMASARKIIESAKVRRKMA

Download         Length: 192 bp

>AT53209 NZ_CP011047:c1232736-1232545 [Cronobacter sakazakii]
ATGCCAAAACATGACTCGCCCGGCGTCTCCAGTCTCAACACCCATAAACAGGCGGAACAGTACAAGCTGTGGTTTCGTGA
AAAAGTGGAAGCCGCAGCGGCAAGCCGCCAGCCCATTACGCCGCATGACGATGTGATGGCAAGCGCGCGCAAGATCATTG
AGAGCGCAAAAGTGAGGAGAAAAATGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UG96

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7US84

References