Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 2774..3692 Replicon plasmid pCC42
Accession NZ_CP011016
Organism Campylobacter coli strain FB1

Toxin (Protein)


Gene name Fic Uniprot ID A0A5T1VVN4
Locus tag VC76_RS08580 Protein ID WP_045243721.1
Coordinates 3009..3692 (+) Length 228 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A0Q2TTN4
Locus tag VC76_RS08575 Protein ID WP_002804094.1
Coordinates 2774..3016 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC76_RS08565 116..1939 + 1824 WP_045243719.1 type IV secretory system conjugative DNA transfer family protein -
VC76_RS08570 1950..2669 + 720 WP_045243720.1 conjugal transfer protein TraL -
VC76_RS08575 2774..3016 + 243 WP_002804094.1 hypothetical protein Antitoxin
VC76_RS08580 3009..3692 + 684 WP_045243721.1 Fic family protein Toxin
VC76_RS08585 3697..4164 + 468 WP_045243722.1 signal peptidase I -
VC76_RS08590 4229..4624 + 396 WP_002782959.1 conjugal transfer protein TraM -
VC76_RS08595 4716..5402 + 687 WP_002782958.1 AAA family ATPase -
VC76_RS08600 5405..5629 + 225 WP_002782956.1 hypothetical protein -
VC76_RS08610 5870..8023 - 2154 WP_045243724.1 relaxase/mobilization nuclease domain-containing protein -
VC76_RS08615 7986..8369 - 384 WP_002804090.1 DNA transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..29115 29115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 228 a.a.        Molecular weight: 26041.28 Da        Isoelectric Point: 10.1734

>T53174 WP_045243721.1 NZ_CP011016:3009-3692 [Campylobacter coli]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKKERIITLQAAKKLELNPIKGNFDYQHLKDIHKALFKDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLISKHKMIHACVEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGMSL

Download         Length: 684 bp

>T53174 NZ_CP011016:3009-3692 [Campylobacter coli]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGATAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAAAAAGAAAGAATAATAACTCTACAAGCCGCTAAAAAATTAGAGCTTA
ATCCAATTAAAGGCAATTTTGATTATCAGCATTTAAAAGATATACATAAAGCACTTTTTAAAGATGTTTATACTTGGGCG
GGACAAGATAGAATGCAAATGGGGCTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCC
TGGAAAAGAGTTAGATAAATACTCTAAAATAATTTTTGATGAACTTGCAAAAAATAATTATCTAAAAAACTCCAAAGATC
TAAATCATTTTGCAAAAAATTTAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCTTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAATGAATTAGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATTTCTAAGCATAAAAT
GATACATGCTTGCGTAGAAGCTTCACAATTAAAACCTGGAAGATTGGAGGCTTTAATTAAAGACAATCTAAAAAACTTTA
GACAAAATTTAGATTTGGAGCAAAATAAAGGAATGTCGTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9452.68 Da        Isoelectric Point: 4.3535

>AT53174 WP_002804094.1 NZ_CP011016:2774-3016 [Campylobacter coli]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEQNKSIICGFAIENMFANEEDIINLIKVDKQEKTPDEIIAEYKKEWGVND

Download         Length: 243 bp

>AT53174 NZ_CP011016:2774-3016 [Campylobacter coli]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGCCTTGCAATACTTAAAAAATATAAAGATGATTTAACCAA
AGAGCAATATGAGCAAAATAAATCTATTATTTGTGGATTTGCTATTGAGAATATGTTTGCAAATGAAGAAGACATTATAA
ATCTCATAAAAGTAGATAAACAAGAAAAAACACCTGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGTGTAAATGAT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T1VVN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q2TTN4

References