Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 296471..297119 Replicon chromosome
Accession NZ_CP011010
Organism Stenotrophomonas maltophilia strain ISMMS3 isolate Patient

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag VN11_RS01310 Protein ID WP_053448528.1
Coordinates 296471..296758 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag VN11_RS01315 Protein ID WP_053448529.1
Coordinates 296817..297119 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VN11_RS22100 291973..295704 - 3732 WP_148564915.1 CDC27 family protein -
VN11_RS01310 296471..296758 + 288 WP_053448528.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VN11_RS01315 296817..297119 + 303 WP_053448529.1 putative addiction module antidote protein Antitoxin
VN11_RS01320 297289..297690 - 402 WP_053448530.1 hypothetical protein -
VN11_RS01325 298276..299046 + 771 Protein_273 DUF3011 domain-containing protein -
VN11_RS01330 299071..299418 - 348 WP_053448531.1 hypothetical protein -
VN11_RS01335 299549..300469 + 921 WP_004153767.1 arginase -
VN11_RS01340 300632..300769 + 138 WP_008266021.1 entericidin A/B family lipoprotein -
VN11_RS01345 300975..301196 + 222 WP_004153772.1 CsbD family protein -
VN11_RS01350 301283..302077 - 795 WP_053448532.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10863.47 Da        Isoelectric Point: 11.1307

>T53169 WP_053448528.1 NZ_CP011010:296471-296758 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTGRARILARIGRLSEGHLGDHRYLADGVSELRIDVGPGYRVYYTQRGRQWVILLAGGDKGS
RQRDIEKAREIARAL

Download         Length: 288 bp

>T53169 NZ_CP011010:296471-296758 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGGGCGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCAGCGAAGGCCATCTGGGCGATCACCGCTATCTGGCCGATGGCGTTTCCGAACTGCGCATCGATG
TGGGACCGGGTTACCGCGTGTACTACACCCAGCGCGGCAGACAGTGGGTGATTCTGCTGGCTGGCGGCGACAAGGGTTCA
CGGCAACGCGATATCGAGAAGGCCAGGGAGATTGCGCGTGCCTTGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10648.28 Da        Isoelectric Point: 9.0171

>AT53169 WP_053448529.1 NZ_CP011010:296817-297119 [Stenotrophomonas maltophilia]
MAIKKKVELKAFDVAEHLRTPEEMAAYLDACIAESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Download         Length: 303 bp

>AT53169 NZ_CP011010:296817-297119 [Stenotrophomonas maltophilia]
ATGGCCATCAAGAAGAAAGTCGAACTCAAAGCATTTGACGTGGCCGAGCACCTTCGTACACCGGAGGAGATGGCGGCCTA
TCTCGATGCTTGCATCGCAGAAAGCGATGGCGATTCTGCGTTCATTGCCAAGGCGCTCGGCGACATCGCACGCGCTCAGG
GGATGAGCAAGGTCGCGCGTGCGGCAGGCCTGTCGCGTGAGAGCCTGTATCGCGCACTGTCGGGCGAGCGCAGCCCCGAT
TTCGCGACCATCCTCAAAGTGACCCGCGCCCTGGGTGTGCGCCTGCATGCCAGCGCAGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References