Detailed information of TA system TA053166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3301988..3302544
• Replicon: chromosome
• Accession: NZ_CP011005
• Organism: Psychromicrobium lacuslunae strain IHBB 11108

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0D4C2H5
• Locus tag: UM93_RS15600
• Protein ID: WP_045076423.1
• Coordinates: 3302269..3302544 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: UM93_RS15595
• Protein ID: WP_052663845.1
• Coordinates: 3301988..3302272 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UM93_RS15570	3297898..3298755	-	858	WP_045076420.1	tRNA glutamyl-Q(34) synthetase GluQRS	-
UM93_RS15580	3299262..3299573	-	312	WP_157874179.1	hypothetical protein	-
UM93_RS15585	3299738..3300844	+	1107	WP_052663844.1	site-specific DNA-methyltransferase	-
UM93_RS15590	3300838..3301749	+	912	WP_199921772.1	hypothetical protein	-
UM93_RS15595	3301988..3302272	+	285	WP_052663845.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
UM93_RS15600	3302269..3302544	+	276	WP_045076423.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UM93_RS15605	3302599..3303072	-	474	WP_199921773.1	ATP-binding protein	-
UM93_RS15610	3303120..3303914	-	795	WP_045076424.1	SDR family oxidoreductase	-
UM93_RS15615	3303988..3304644	-	657	WP_199921774.1	NAD(P)H-dependent oxidoreductase	-
UM93_RS15620	3304659..3306122	-	1464	WP_045076426.1	MFS transporter	-
UM93_RS15625	3306208..3306648	+	441	WP_082057195.1	MarR family transcriptional regulator	-
UM93_RS15630	3306629..3307531	-	903	WP_045076427.1	DUF2236 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10425.00 Da
• Isoelectric Point: 10.4958

>T53166 WP_045076423.1 NZ_CP011005:3302269-3302544 [Psychromicrobium lacuslunae]
VSQKYEVRFSKSARRALTHALPEKVAAAAFEFITGNLAANPQRLGKQLGEPFYPLFSARRGEYRVIYSILEREIVIEIVS
ILHRRDAYRSS

Nucleotide

• Length: 276 bp

>T53166 NZ_CP011005:3302269-3302544 [Psychromicrobium lacuslunae]
GTGAGCCAAAAGTACGAGGTCCGATTCAGTAAGTCCGCACGTAGAGCGTTGACTCACGCTCTCCCTGAGAAGGTGGCTGC
GGCGGCATTCGAATTTATTACCGGCAACCTGGCGGCGAATCCTCAACGCCTCGGGAAACAGCTCGGCGAACCTTTCTATC
CGCTATTTTCAGCACGCCGCGGCGAATATCGGGTCATTTATTCGATTCTCGAACGCGAAATTGTCATCGAGATTGTTTCG
ATTTTGCATCGTCGTGACGCCTATCGGAGTTCTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10132.22 Da
• Isoelectric Point: 4.4978

>AT53166 WP_052663845.1 NZ_CP011005:3301988-3302272 [Psychromicrobium lacuslunae]
MSTLSLAEARASFSRLVDSAASTHERFEITRNGNRAAVLLGADDYDSLLETVAILSDADAVAAVRKGIAEFNSDQTFSAD
EVREELIRSGRIKA

Nucleotide

• Length: 285 bp

>AT53166 NZ_CP011005:3301988-3302272 [Psychromicrobium lacuslunae]
ATGAGTACATTATCGTTGGCAGAAGCTCGGGCTAGCTTTTCACGTCTGGTTGACTCGGCTGCAAGCACTCATGAGCGGTT
CGAGATCACCCGTAACGGCAATCGTGCCGCTGTGCTTCTCGGTGCCGATGACTATGACAGCTTGCTCGAAACAGTCGCCA
TATTGAGTGATGCGGATGCTGTTGCTGCGGTTCGGAAGGGGATCGCTGAGTTCAATAGCGATCAGACTTTCTCCGCCGAT
GAAGTGCGAGAAGAACTTATTCGGTCGGGGCGCATCAAGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0D4C2H5