Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 24637..25114 Replicon chromosome
Accession NZ_CP010998
Organism Staphylococcus aureus strain FORC_012 isolate human sputum

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC12_RS00120 Protein ID WP_000052076.1
Coordinates 24637..24825 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC12_RS00125 Protein ID WP_001059690.1
Coordinates 24854..25114 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC12_RS00090 20627..21148 + 522 WP_000824484.1 hypothetical protein -
FORC12_RS00095 21489..22175 + 687 WP_001792695.1 thermonuclease family protein -
FORC12_RS00100 22532..22732 + 201 WP_001059082.1 cold-shock protein -
FORC12_RS00105 23228..23446 - 219 WP_000005886.1 hypothetical protein -
FORC12_RS00110 23508..23792 - 285 WP_001004395.1 hypothetical protein -
FORC12_RS00115 23880..24449 - 570 WP_001106654.1 hypothetical protein -
FORC12_RS00120 24637..24825 - 189 WP_000052076.1 hypothetical protein Toxin
FORC12_RS00125 24854..25114 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC12_RS00130 25455..25658 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC12_RS00135 25655..25891 - 237 WP_000368687.1 hypothetical protein -
FORC12_RS00140 26116..26697 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FORC12_RS00145 26770..27387 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FORC12_RS00150 27542..28036 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC12_RS00155 28435..28857 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC12_RS00160 29005..29721 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T53150 WP_000052076.1 NZ_CP010998:c24825-24637 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T53150 NZ_CP010998:c24825-24637 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT53150 WP_001059690.1 NZ_CP010998:c25114-24854 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT53150 NZ_CP010998:c25114-24854 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References