53146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6563954..6565635 Replicon chromosome
Accession NZ_CP010979
Organism Pseudomonas putida S13.1.2

Toxin (Protein)


Gene name doc Uniprot ID A0A0C5RRY8
Locus tag N805_RS29090 Protein ID WP_019473500.1
Coordinates 6564778..6565635 (-) Length 286 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N805_RS29085 Protein ID WP_026034667.1
Coordinates 6563954..6564772 (-) Length 273 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N805_RS29065 6559165..6560655 - 1491 WP_019473495.1 aldehyde dehydrogenase -
N805_RS29070 6560666..6561469 - 804 WP_019473496.1 aspartate dehydrogenase -
N805_RS29075 6561480..6563162 - 1683 WP_019473497.1 thiamine pyrophosphate-binding protein -
N805_RS29080 6563155..6563952 - 798 WP_019473498.1 SDR family oxidoreductase -
N805_RS29085 6563954..6564772 - 819 WP_026034667.1 IclR family transcriptional regulator Antitoxin
N805_RS29090 6564778..6565635 - 858 WP_019473500.1 alpha/beta fold hydrolase Toxin
N805_RS29095 6565640..6566179 - 540 WP_019473501.1 cupin domain-containing protein -
N805_RS29100 6566195..6566962 - 768 WP_019473502.1 SDR family oxidoreductase -
N805_RS29105 6566959..6567735 - 777 WP_019473503.1 ABC transporter permease -
N805_RS29110 6567765..6568775 - 1011 WP_019473504.1 ABC transporter substrate-binding protein -
N805_RS29115 6568807..6569652 - 846 WP_019473505.1 ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(43-268)

Antitoxin

(131-253)


Sequences


Toxin        


Download         Length: 286 a.a.        Molecular weight: 30308.98 Da        Isoelectric Point: 7.5315

>T53146 WP_019473500.1 NZ_CP010979:c6565635-6564778 [Pseudomonas putida S13.1.2]
MMPITPIAPLLGQLDQRFAERLLRLDQGQQAVREAGSGQAMMLLHGIGSGAASWLQVALGLSERARVIAWDAPGYGQSTP
LPMAAPKAGDYAARLLHTLDALDIERCVLVGHSLGALTAAAFAQAHPARVSRLVLLSPARGYGEQPEQGQAVRSKRLHTL
EHMGIEHMARERSAHLLSASASTQALAWVHWNMARLLPHGYRQAIELLCGDHLLRFAPPTVPCEVHCGSADAITPARDCQ
ALAEALGAPFKLIPGAGHACAIEQPDRVTGLLARALDTSLTGSVL

Download         Length: 858 bp

>T53146 NZ_CP010979:c6565635-6564778 [Pseudomonas putida S13.1.2]
ATGATGCCGATCACCCCCATTGCCCCACTGCTCGGGCAACTCGACCAGCGCTTCGCCGAGCGCCTGCTACGCCTGGACCA
AGGCCAGCAAGCGGTGCGCGAGGCTGGCAGTGGCCAGGCCATGATGCTGCTGCACGGCATAGGGTCGGGCGCGGCCAGCT
GGTTGCAAGTGGCCTTGGGCCTGAGCGAGCGGGCGCGGGTGATCGCCTGGGACGCCCCGGGCTACGGCCAGTCCACGCCA
CTGCCAATGGCTGCGCCCAAGGCCGGCGACTATGCCGCCCGCCTGCTGCACACGCTCGACGCCTTGGACATCGAACGCTG
CGTGCTGGTGGGCCATTCCCTCGGCGCGCTGACCGCCGCCGCTTTTGCCCAGGCCCACCCGGCCCGGGTCAGCCGCCTGG
TACTGCTGAGCCCGGCGCGCGGCTACGGGGAGCAACCCGAGCAAGGCCAGGCCGTACGCAGCAAGCGCCTGCACACCCTG
GAGCACATGGGCATCGAGCACATGGCCCGTGAGCGCAGCGCGCACTTGCTGTCTGCCAGCGCCAGCACCCAAGCGCTGGC
CTGGGTGCACTGGAACATGGCGCGGCTGCTGCCGCACGGCTACCGCCAAGCCATCGAGCTGTTGTGCGGCGACCATCTGC
TGCGCTTTGCGCCGCCGACCGTGCCCTGCGAAGTGCACTGCGGCAGCGCCGATGCCATCACCCCCGCGCGCGACTGCCAG
GCCCTGGCCGAGGCACTGGGCGCGCCTTTCAAGCTGATACCTGGCGCCGGCCATGCCTGCGCCATCGAACAACCTGACAG
GGTGACGGGCTTGCTTGCCCGTGCCCTGGACACCTCCCTCACAGGTAGCGTGCTATGA

Antitoxin


Download         Length: 273 a.a.        Molecular weight: 30009.55 Da        Isoelectric Point: 6.6424

>AT53146 WP_026034667.1 NZ_CP010979:c6564772-6563954 [Pseudomonas putida S13.1.2]
MDPLKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLGELR
ELYPEEHLEQFSACTPKTVLELFDLVQADRLRGYVSGEGFFEPSISTVAAPVRDVSGQVVAALGLTIPTVQIGHVNFDNM
LGQVRNSADELSRLLNYTPNAGHGRVTALMRD

Download         Length: 819 bp

>AT53146 NZ_CP010979:c6564772-6563954 [Pseudomonas putida S13.1.2]
ATGGATCCGTTGAAGGAAAACCAGGACAAGTACATTGTTCCGGGCCTGGAACGCGGCCTGCTACTGCTGTGCGAATTCAG
CCGGCAGAACCGTACCCTGACCGCCCCCGAGCTGGCCCGACGCCTGTCGCTACCACGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAAACCATGGGCTTCGTCACCCGCAGCGGCAACGAGTACCGCCTCGGCATGTCGGTGCTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACAGAGCTCGGCCAGCCACTGTTGGCACGGCTGTGCGACCACCTCAACTACCCGAG
CAACCTGGTGGTGCGCGACGGCCGCTCGATCGTCTACGTGGCCAAGGTCTCGCCACCCTCGGTGTTCTCCAGTGCGGTCA
CCGTCGGCACCCGCCTCCCCGCCCATGCCACAGTACTGGGTCGCATCCTGCTGGCTGACCTGAGCCTGGGCGAACTGCGC
GAACTGTACCCGGAAGAGCACCTGGAGCAGTTTTCAGCGTGCACGCCAAAAACCGTGCTGGAACTCTTCGACCTGGTCCA
GGCCGACCGCCTGCGGGGCTATGTCAGCGGCGAAGGCTTTTTCGAACCGAGCATCTCCACGGTCGCAGCGCCGGTGCGCG
ATGTCAGCGGCCAGGTGGTCGCCGCGCTCGGCCTGACCATACCCACCGTGCAGATCGGCCACGTCAATTTCGACAACATG
CTGGGCCAGGTACGCAATAGCGCCGATGAGCTGTCGCGGCTGCTCAACTACACACCCAACGCAGGCCACGGCCGCGTCAC
CGCCCTGATGAGGGATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0C5RRY8


Antitoxin

Source ID Structure

References