53135

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 5588627..5589228 Replicon chromosome
Accession NZ_CP010976
Organism Paenibacillus sp. IHBB 10380 isolate IHBB

Toxin (Protein)


Gene name mazF Uniprot ID A0A0D3VFW1
Locus tag UB51_RS25250 Protein ID WP_044879665.1
Coordinates 5588627..5588956 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0D3VFU7
Locus tag UB51_RS25255 Protein ID WP_044879666.1
Coordinates 5588953..5589228 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UB51_RS25225 5583823..5584176 - 354 WP_044879660.1 helix-turn-helix domain-containing protein -
UB51_RS25230 5584323..5584814 + 492 WP_044879661.1 hypothetical protein -
UB51_RS25235 5585283..5586428 + 1146 WP_044879662.1 DUF418 domain-containing protein -
UB51_RS25240 5586468..5587583 + 1116 WP_044879663.1 sensor histidine kinase -
UB51_RS25245 5587586..5588191 + 606 WP_044879664.1 response regulator transcription factor -
UB51_RS25250 5588627..5588956 - 330 WP_044879665.1 endoribonuclease MazF Toxin
UB51_RS25255 5588953..5589228 - 276 WP_044879666.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
UB51_RS25260 5589683..5591425 + 1743 WP_044879667.1 ATP-binding cassette domain-containing protein -
UB51_RS25265 5591950..5592201 - 252 WP_044879668.1 helix-turn-helix domain-containing protein -
UB51_RS25270 5592448..5592936 + 489 WP_052676078.1 hypothetical protein -
UB51_RS25275 5593294..5593584 + 291 WP_044879669.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(12-90)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12001.70 Da        Isoelectric Point: 7.1333

>T53135 WP_044879665.1 NZ_CP010976:c5588956-5588627 [Paenibacillus sp. IHBB 10380]
VSVPDRGDLVYLSFDPQAGHEQSGRRPAIVLSPKAFNQATGFAAFCPITNQSKGYPFEVKLTEEDKITGVILSDQIKTLG
WKARRCEIVGQAPISVTQEVLDKIHTFLN

Download         Length: 330 bp

>T53135 NZ_CP010976:c5588956-5588627 [Paenibacillus sp. IHBB 10380]
GTGAGTGTTCCCGACCGTGGCGATTTGGTCTATCTAAGTTTTGACCCACAAGCAGGACACGAACAATCTGGAAGAAGGCC
AGCTATCGTGTTATCCCCGAAGGCCTTTAATCAAGCCACCGGATTCGCTGCCTTCTGTCCCATCACCAATCAATCGAAGG
GTTATCCATTTGAAGTAAAGCTAACTGAGGAAGATAAGATAACCGGAGTGATTTTGAGCGATCAGATAAAAACCTTAGGT
TGGAAAGCACGTCGTTGCGAAATTGTTGGACAAGCCCCTATTTCCGTTACACAAGAAGTTTTAGACAAAATTCATACCTT
TCTGAACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9994.43 Da        Isoelectric Point: 6.4652

>AT53135 WP_044879666.1 NZ_CP010976:c5589228-5588953 [Paenibacillus sp. IHBB 10380]
MDLSNGKRVSAMSVKVQKWGNSLALRIPVQFTSKLGIGEGTEMHLDFDDKGGLSLVPVIQKPTLEELLSQITPTNRHKEI
DFGKSEGNESL

Download         Length: 276 bp

>AT53135 NZ_CP010976:c5589228-5588953 [Paenibacillus sp. IHBB 10380]
ATGGATTTATCAAATGGGAAAAGGGTGAGCGCAATGTCTGTTAAAGTACAAAAGTGGGGGAACAGTTTAGCTTTACGAAT
TCCTGTGCAATTCACCTCAAAATTAGGTATTGGTGAAGGTACTGAAATGCATTTAGATTTCGATGATAAGGGTGGTCTAA
GCTTAGTTCCTGTAATACAAAAGCCGACGCTGGAAGAATTGCTTTCTCAAATCACCCCAACAAATCGGCACAAAGAAATA
GACTTTGGAAAATCAGAAGGGAATGAATCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D3VFW1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D3VFU7

References