Detailed information of TA system TA053134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3793022..3793648
• Replicon: chromosome
• Accession: NZ_CP010976
• Organism: Paenibacillus sp. IHBB 10380 isolate IHBB

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A0D3VCW8
• Locus tag: UB51_RS17115
• Protein ID: WP_044878339.1
• Coordinates: 3793022..3793372 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: UB51_RS17120
• Protein ID: WP_199924945.1
• Coordinates: 3793376..3793648 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UB51_RS17095	3788573..3788896	+	324	WP_044878335.1	hypothetical protein	-
UB51_RS17100	3789025..3789888	+	864	WP_044878336.1	NAD(P)-dependent oxidoreductase	-
UB51_RS17105	3790168..3790941	-	774	WP_044878337.1	alpha/beta hydrolase	-
UB51_RS17110	3791245..3792858	+	1614	WP_044878338.1	alkaline phosphatase family protein	-
UB51_RS17115	3793022..3793372	-	351	WP_044878339.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
UB51_RS17120	3793376..3793648	-	273	WP_199924945.1	ribbon-helix-helix protein, CopG family	Antitoxin
UB51_RS17125	3793863..3795047	-	1185	WP_044880247.1	alanine racemase	-
UB51_RS17130	3795265..3796359	-	1095	WP_044878340.1	outer membrane lipoprotein carrier protein LolA	-
UB51_RS17135	3796584..3796907	-	324	WP_044878341.1	(2Fe-2S)-binding protein	-
UB51_RS17140	3797184..3798368	+	1185	WP_044876240.1	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3797184..3798368	1184

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12870.81 Da
• Isoelectric Point: 5.1284

>T53134 WP_044878339.1 NZ_CP010976:c3793372-3793022 [Paenibacillus sp. IHBB 10380]
MIFKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDEALQISLSLIDF

Nucleotide

• Length: 351 bp

>T53134 NZ_CP010976:c3793372-3793022 [Paenibacillus sp. IHBB 10380]
TTGATTTTTAAACGCGGCGACGTATTTTTCGCGGACCTTTCTCCTGTTGTTGGTTCCGAACAGGGAGGGGTCAGGCCAGT
ATTGATCATTCAGAATGACATTGGTAATCGGTTTAGTCCGACGGTTATTGTGGCGGCTATTACGGCTCAAATCCAGAAGG
CAAAGCTGCCCACCCATGTGGAGATTGACGCAGCATCCCATGGATTCGATCGTGATTCCGTTATTCTGCTTGAACAGGTT
CGGACCATTGACAAACAAAGACTAACGGATAAGATTACTCATCTTGACGACGAAACAATGAAAAAAGTAGATGAAGCCTT
ACAAATCAGTTTGAGTTTAATTGATTTTTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10375.89 Da
• Isoelectric Point: 7.2027

>AT53134 WP_199924945.1 NZ_CP010976:c3793648-3793376 [Paenibacillus sp. IHBB 10380]
MQNTKRIMISLPDHLLQEVDGIAQLENSNRSELIRQAMKLYLTERKKRYIRESMQRGYMEMAKINLTMASEAFHAEEDAD
STLGRSVSGV

Nucleotide

• Length: 273 bp

>AT53134 NZ_CP010976:c3793648-3793376 [Paenibacillus sp. IHBB 10380]
ATGCAGAACACCAAGAGAATAATGATCAGTTTGCCAGATCATCTTTTGCAGGAAGTGGACGGGATTGCTCAGCTGGAGAA
TTCCAACCGTAGTGAACTTATCAGGCAAGCCATGAAACTGTATCTGACAGAACGGAAGAAACGGTACATCCGAGAGTCTA
TGCAGCGTGGTTATATGGAAATGGCCAAGATTAACTTGACCATGGCGTCTGAGGCCTTTCATGCGGAAGAAGATGCAGAC
AGCACTCTAGGCCGCTCAGTAAGCGGGGTGTAG

Structures

Toxin

• AlphaFold DB: A0A0D3VCW8