Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 298016..298575 Replicon plasmid 3pYBL2-3
Accession NZ_CP010957
Organism Sphingobium sp. YBL2

Toxin (Protein)


Gene name relE Uniprot ID A0A7S9YXZ6
Locus tag TZ53_RS24920 Protein ID WP_044663546.1
Coordinates 298016..298309 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S9YZD2
Locus tag TZ53_RS24925 Protein ID WP_044663547.1
Coordinates 298306..298575 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TZ53_RS24900 293528..294841 + 1314 WP_044663544.1 chloride channel protein -
TZ53_RS24905 295125..295784 + 660 WP_044663545.1 FABP family protein -
TZ53_RS24910 295946..296869 + 924 WP_197565263.1 hypothetical protein -
TZ53_RS24915 297136..297876 + 741 WP_052628307.1 energy transducer TonB -
TZ53_RS24920 298016..298309 - 294 WP_044663546.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TZ53_RS24925 298306..298575 - 270 WP_044663547.1 ribbon-helix-helix domain-containing protein Antitoxin
TZ53_RS24930 299102..299446 + 345 WP_044663548.1 RcnB family protein -
TZ53_RS24935 299522..300241 + 720 WP_044663549.1 response regulator -
TZ53_RS24940 300238..301599 + 1362 WP_044663550.1 HAMP domain-containing histidine kinase -
TZ53_RS24945 302021..302215 + 195 WP_044663551.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..322226 322226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11424.09 Da        Isoelectric Point: 7.4224

>T53117 WP_044663546.1 NZ_CP010957:c298309-298016 [Sphingobium sp. YBL2]
MKIQWTGKASSDLVRLHEHLRPVAPEAAARVVQQLARAPDRLLDYPRIGEKLEAYEPREVRRIIVGHHELRYEIADAIIF
ILRLWHCRENRSFDSDD

Download         Length: 294 bp

>T53117 NZ_CP010957:c298309-298016 [Sphingobium sp. YBL2]
ATGAAGATACAGTGGACCGGCAAGGCGTCGTCGGACCTGGTGCGCCTTCATGAGCATCTGCGCCCGGTAGCGCCGGAAGC
TGCGGCACGGGTCGTTCAGCAGCTTGCCCGGGCGCCGGACCGGCTGCTCGACTACCCGCGGATCGGAGAGAAGCTGGAAG
CCTATGAACCGCGCGAGGTGCGGCGGATCATCGTCGGTCATCACGAGCTTCGCTACGAGATTGCGGACGCCATCATCTTC
ATTCTGCGCCTGTGGCACTGCCGCGAGAATCGCAGCTTCGATTCCGATGACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9904.29 Da        Isoelectric Point: 5.6158

>AT53117 WP_044663547.1 NZ_CP010957:c298575-298306 [Sphingobium sp. YBL2]
MATETKVLTAHVPLSLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEALADVDAGRVIDHQSIQSWADSLST
DKPLPPPAK

Download         Length: 270 bp

>AT53117 NZ_CP010957:c298575-298306 [Sphingobium sp. YBL2]
ATGGCAACTGAAACGAAGGTTCTGACGGCGCATGTGCCACTTTCGCTTGCGGAAAAGGTCGAGGCAATGGCTTCCCGGCT
GGAACGCTCGCGCGGCTGGGTGATGAAGCAGGCGCTCGCCGCCTGGGTCGATCAGGAGGAAGAGCGCCATCGGATGACGC
TCGAAGCGCTGGCGGACGTCGACGCGGGCCGGGTTATCGATCATCAAAGCATTCAGTCATGGGCGGACAGCCTCAGCACA
GACAAGCCGCTGCCGCCGCCGGCAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S9YXZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A7S9YZD2

References