Detailed information of TA system TA053116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 101916..102850
• Replicon: plasmid 2pYBL2-2
• Accession: NZ_CP010956
• Organism: Sphingobium sp. YBL2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: TZ53_RS22885
• Protein ID: WP_044663258.1
• Coordinates: 102332..102850 (+)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C5XZS7
• Locus tag: TZ53_RS22880
• Protein ID: WP_044663257.1
• Coordinates: 101916..102266 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TZ53_RS22860	97259..97585	-	327	WP_044663253.1	single-stranded DNA-binding protein	-
TZ53_RS22865	98250..99338	+	1089	WP_044663254.1	replication initiation protein	-
TZ53_RS22870	99533..100735	+	1203	WP_044663255.1	AAA family ATPase	-
TZ53_RS22875	100783..101796	+	1014	WP_172668340.1	ParB/RepB/Spo0J family partition protein	-
TZ53_RS22880	101916..102266	+	351	WP_044663257.1	DUF2384 domain-containing protein	Antitoxin
TZ53_RS22885	102332..102850	+	519	WP_044663258.1	RES family NAD+ phosphorylase	Toxin
TZ53_RS22890	102847..104013	-	1167	WP_044663259.1	hypothetical protein	-
TZ53_RS22895	104160..105398	+	1239	WP_044663260.1	site-specific integrase	-
TZ53_RS22900	105709..105915	-	207	WP_022684351.1	hypothetical protein	-
TZ53_RS22905	106060..107361	+	1302	WP_022684350.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..227503	227503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-152)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (65-113)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 18277.86 Da
• Isoelectric Point: 6.7178

>T53116 WP_044663258.1 NZ_CP010956:102332-102850 [Sphingobium sp. YBL2]
MTYALAPLSLPLWRMIGIRHQFSPTSGEGARLYGGRWNRKGYSALYLAADAVTAVAEYYQGLPKPGTLVPYHLDASAITD
LTNATAGPCDARVAEALAANWKAMALLDGKTPPSWALTEELIAAGAQGALVPSVQNPGGRNLVLWQWHEKGLQGEGAALT
VLDPDDALKAPR

Nucleotide

• Length: 519 bp

>T53116 NZ_CP010956:102332-102850 [Sphingobium sp. YBL2]
ATGACCTATGCTCTTGCGCCGTTGTCGCTTCCGCTCTGGCGGATGATCGGGATCCGCCATCAGTTCAGTCCGACGTCCGG
AGAAGGCGCGCGGCTCTATGGGGGCCGCTGGAACCGCAAAGGATATTCAGCGCTCTATCTGGCGGCCGATGCGGTCACAG
CCGTGGCTGAATACTATCAAGGGCTGCCCAAGCCCGGGACGCTTGTCCCTTATCACCTCGACGCATCGGCGATCACGGAT
CTCACCAATGCTACCGCCGGCCCCTGCGATGCGCGCGTTGCCGAGGCCTTGGCTGCGAACTGGAAGGCGATGGCGTTGCT
CGATGGCAAGACGCCGCCGAGTTGGGCGCTGACAGAGGAATTGATCGCGGCGGGTGCGCAAGGCGCGCTTGTGCCGTCGG
TCCAGAATCCCGGTGGTCGGAACCTGGTGCTGTGGCAATGGCATGAGAAGGGTCTTCAAGGGGAAGGAGCCGCGCTGACT
GTCCTTGATCCTGACGATGCCCTGAAAGCTCCCCGCTAA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 12758.72 Da
• Isoelectric Point: 6.4863

>AT53116 WP_044663257.1 NZ_CP010956:101916-102266 [Sphingobium sp. YBL2]
MLAAFLDDIRDGDMIAPRRMAERLRLPMTRLSRLAHLNRNTMTTHPGSPAVQAKLGEIARIIARAAELAGDEGKAIIWFK
HQPLPGFGKTAEELVEDGHADVVIEDLDRMAAGVYS

Nucleotide

• Length: 351 bp

>AT53116 NZ_CP010956:101916-102266 [Sphingobium sp. YBL2]
ATGCTTGCCGCATTTTTGGACGATATTCGTGATGGCGACATGATCGCGCCGCGCCGCATGGCGGAACGCCTGCGCCTACC
GATGACGCGTCTATCGCGACTTGCGCACCTCAATCGCAACACCATGACCACACACCCCGGCAGCCCGGCTGTGCAGGCCA
AGCTGGGGGAAATTGCCCGGATCATCGCGCGAGCGGCTGAGCTCGCGGGCGATGAAGGCAAGGCGATCATCTGGTTCAAG
CATCAGCCTCTGCCCGGATTTGGCAAGACGGCTGAGGAATTGGTCGAGGATGGCCATGCTGATGTCGTGATCGAGGATCT
CGATCGTATGGCCGCCGGTGTTTATTCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C5XZS7