Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4586570..4587027 Replicon chromosome
Accession NZ_CP010954
Organism Sphingobium sp. YBL2

Toxin (Protein)


Gene name relE Uniprot ID A0A4Q4J3V7
Locus tag TZ53_RS21225 Protein ID WP_044662619.1
Coordinates 4586752..4587027 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A292ZD49
Locus tag TZ53_RS21220 Protein ID WP_044662618.1
Coordinates 4586570..4586752 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TZ53_RS21200 (TZ53_21220) 4581689..4584601 + 2913 WP_044662615.1 excinuclease ABC subunit UvrA -
TZ53_RS21205 (TZ53_21225) 4584677..4585753 + 1077 WP_044662616.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
TZ53_RS26285 4585761..4586321 + 561 WP_083199195.1 hypothetical protein -
TZ53_RS21215 (TZ53_21235) 4586299..4586493 + 195 WP_099185664.1 hypothetical protein -
TZ53_RS21220 (TZ53_21240) 4586570..4586752 + 183 WP_044662618.1 hypothetical protein Antitoxin
TZ53_RS21225 (TZ53_21245) 4586752..4587027 + 276 WP_044662619.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
TZ53_RS21230 (TZ53_21250) 4587111..4588112 + 1002 WP_044662620.1 hypothetical protein -
TZ53_RS21235 (TZ53_21255) 4588283..4588495 + 213 WP_007684722.1 cold-shock protein -
TZ53_RS27245 4588558..4588734 + 177 WP_171010079.1 hypothetical protein -
TZ53_RS21240 (TZ53_21260) 4588863..4589081 + 219 WP_025550213.1 hypothetical protein -
TZ53_RS21245 (TZ53_21265) 4589252..4589596 + 345 WP_025550214.1 glycine zipper 2TM domain-containing protein -
TZ53_RS21250 (TZ53_21270) 4589654..4590586 - 933 WP_044662621.1 FAD-binding protein -
TZ53_RS21255 (TZ53_21275) 4590583..4591332 - 750 WP_044663190.1 electron transfer flavoprotein subunit beta/FixA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10438.92 Da        Isoelectric Point: 6.4801

>T53114 WP_044662619.1 NZ_CP010954:4586752-4587027 [Sphingobium sp. YBL2]
MPHVIWRPKALEDADRIIDYISDRNPAAAARLADLFEYAAERLADHPYMHRAGRVPDTREAIVTPNYILVYRAGADVIEI
LAILHTRQQYP

Download         Length: 276 bp

>T53114 NZ_CP010954:4586752-4587027 [Sphingobium sp. YBL2]
ATGCCGCACGTCATCTGGCGCCCGAAGGCGCTCGAAGATGCCGACCGCATCATCGACTATATCTCCGACCGCAATCCCGC
CGCTGCCGCCCGCCTTGCCGATCTGTTCGAATATGCCGCTGAGCGACTGGCCGACCATCCCTATATGCATCGCGCCGGTC
GCGTCCCGGATACGCGGGAAGCCATCGTTACCCCCAACTATATTCTCGTTTACCGCGCAGGCGCAGACGTCATCGAAATA
CTGGCCATCCTCCACACCCGCCAACAATATCCTTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6641.62 Da        Isoelectric Point: 5.7833

>AT53114 WP_044662618.1 NZ_CP010954:4586570-4586752 [Sphingobium sp. YBL2]
MTKLTPIESEFATTEDAEAYDAWFRAKVEAALADPRPGIPHDQVMAKLRAIIEAKKAKQA

Download         Length: 183 bp

>AT53114 NZ_CP010954:4586570-4586752 [Sphingobium sp. YBL2]
ATGACAAAACTCACTCCCATCGAGTCCGAGTTCGCGACCACCGAGGACGCCGAGGCCTATGACGCTTGGTTCCGCGCCAA
GGTCGAAGCCGCCTTGGCCGATCCCCGACCCGGCATCCCGCACGATCAGGTCATGGCGAAACTGCGCGCCATCATTGAGG
CCAAGAAAGCCAAGCAGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q4J3V7

Antitoxin

Source ID Structure
AlphaFold DB A0A292ZD49

References