Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 228877..230346 Replicon chromosome
Accession NZ_CP010904
Organism Kiritimatiella glycovorans strain L21-Fru-AB

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A0G3EAK7
Locus tag L21SP4_RS01045 Protein ID WP_052880922.1
Coordinates 229105..230346 (+) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A0G3EFD6
Locus tag L21SP4_RS01040 Protein ID WP_052880921.1
Coordinates 228877..229086 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L21SP4_RS01020 224547..225197 - 651 WP_074041325.1 phosphoribosylanthranilate isomerase -
L21SP4_RS01025 225214..225870 - 657 WP_052880918.1 NAD(P)H-dependent oxidoreductase -
L21SP4_RS01030 225982..227160 - 1179 WP_052880919.1 serine/threonine protein kinase -
L21SP4_RS01035 227157..228368 - 1212 WP_052880920.1 tryptophan synthase subunit beta -
L21SP4_RS01040 228877..229086 + 210 WP_052880921.1 helix-turn-helix transcriptional regulator Antitoxin
L21SP4_RS01045 229105..230346 + 1242 WP_052880922.1 type II toxin-antitoxin system HipA family toxin Toxin
L21SP4_RS01050 230638..231543 - 906 WP_082116420.1 ribosomal RNA small subunit methyltransferase A -
L21SP4_RS01055 231471..232463 - 993 WP_052880924.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-375)

Antitoxin

Transcription regulator, HipB-like

(7-62)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 46299.98 Da        Isoelectric Point: 6.7633

>T53073 WP_052880922.1 NZ_CP010904:229105-230346 [Kiritimatiella glycovorans]
MRRLFVYLNDEHVGALDQDDSGLLLFRYAPSWLNRPDAIPLSRSLPLREEPFRGKYARPFFAGVLPDETPRRRIASILGI
SERNDFAMLERIGGECAGAVRLLPDDAAARTEDAEALHKFGEDELKRVFAELPQRPLMAGKEGVRLSLAGAQGKLPVVVR
GGSICLPLNNTASTHILKPEPESFRGLAANESFCMRLAGEAGLNVPPVEMRNTNGLPYLVIERFDRDEDKSGRVRRIHQE
DFCQALGYPPEHKYQQEGGPLLRHGFELLRDWSTAPVLDVLELVDTMIFNAVIGNADAHGKNFSLLYRGHERRLAPAYDL
VCTLAWPEISTRLAMNIGGCRTLTEIRPDHWRRMAEETGLAWPMLRERVARFATEIGEAACRLRENLSVRDPMIDRVAEI
IASRADRMGSGRG

Download         Length: 1242 bp

>T53073 NZ_CP010904:229105-230346 [Kiritimatiella glycovorans]
ATGCGTCGTCTTTTCGTTTACTTGAACGACGAGCACGTTGGGGCGCTGGATCAGGACGACAGCGGATTGTTGCTTTTCCG
TTACGCTCCGTCGTGGCTGAATCGGCCGGATGCGATACCGCTCTCCCGCAGTCTTCCGCTGCGCGAGGAACCATTCCGCG
GGAAATATGCACGACCCTTTTTTGCGGGCGTGCTTCCCGACGAGACTCCGCGCAGGCGTATCGCCTCGATCCTCGGGATC
AGTGAGCGCAACGACTTCGCCATGCTCGAACGGATTGGCGGCGAGTGCGCGGGGGCGGTCAGGCTGCTTCCCGACGATGC
CGCCGCCCGGACCGAGGATGCAGAGGCGCTGCATAAATTCGGCGAAGACGAACTGAAGCGTGTTTTTGCGGAACTGCCGC
AGCGTCCCCTCATGGCGGGAAAAGAGGGTGTGAGGCTTTCGCTGGCGGGGGCTCAGGGGAAACTCCCGGTCGTCGTGCGT
GGCGGATCGATCTGCCTTCCTCTGAACAACACCGCGAGCACGCATATCCTGAAACCGGAACCTGAAAGTTTCCGCGGATT
AGCGGCGAATGAATCATTCTGCATGAGACTGGCGGGGGAGGCCGGATTGAACGTCCCGCCCGTTGAAATGAGGAACACGA
ACGGTCTTCCTTATCTCGTGATCGAACGCTTCGATCGAGATGAGGATAAAAGCGGCCGCGTGCGTCGCATACATCAGGAG
GATTTCTGCCAGGCGCTGGGGTATCCGCCGGAACACAAGTATCAGCAGGAGGGCGGTCCGCTGCTCCGACATGGCTTCGA
ACTCCTGCGGGACTGGTCCACGGCACCCGTGCTGGATGTCCTGGAACTGGTCGATACGATGATCTTCAATGCGGTGATCG
GCAACGCGGACGCCCACGGGAAGAATTTCTCCCTCCTCTATCGCGGACATGAACGGAGACTCGCCCCCGCCTACGACCTC
GTCTGCACCCTGGCCTGGCCCGAAATCTCCACTCGGCTCGCGATGAATATCGGGGGGTGCCGCACACTCACGGAAATCAG
GCCGGATCACTGGCGACGGATGGCCGAAGAAACCGGACTCGCCTGGCCGATGCTCCGGGAGCGCGTGGCCCGTTTCGCGA
CGGAGATCGGCGAGGCCGCCTGTAGATTGCGCGAGAATCTATCCGTCCGGGATCCCATGATCGACCGCGTGGCGGAGATC
ATCGCCTCCCGCGCGGACCGGATGGGTTCCGGGCGGGGATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7603.04 Da        Isoelectric Point: 10.8853

>AT53073 WP_052880921.1 NZ_CP010904:228877-229086 [Kiritimatiella glycovorans]
MKIENTEQLGAAVRRRRKRMGITQKDLAMVCGTGLRFIVDLEKGKPTCQTGKALQVLKALGMGVDVESR

Download         Length: 210 bp

>AT53073 NZ_CP010904:228877-229086 [Kiritimatiella glycovorans]
ATGAAGATAGAAAACACAGAGCAGTTGGGTGCGGCGGTGCGGCGTCGGCGCAAACGAATGGGGATCACGCAGAAGGATCT
CGCCATGGTTTGCGGGACGGGTTTGCGATTCATCGTGGACCTGGAGAAGGGCAAGCCCACCTGTCAGACCGGGAAGGCGC
TTCAGGTGCTCAAGGCGCTTGGAATGGGCGTCGACGTCGAATCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3EAK7

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3EFD6

References