Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 83860..84413 Replicon plasmid pPV15
Accession NZ_CP010898
Organism Pandoraea vervacti strain NS15

Toxin (Protein)


Gene name relE Uniprot ID A0A0C5KJQ9
Locus tag UC34_RS25000 Protein ID WP_044458674.1
Coordinates 83860..84153 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C5JXW2
Locus tag UC34_RS25005 Protein ID WP_044458675.1
Coordinates 84141..84413 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UC34_RS24985 79732..80775 - 1044 WP_044458671.1 ParB N-terminal domain-containing protein -
UC34_RS24990 80779..82008 - 1230 WP_044458672.1 AAA family ATPase -
UC34_RS24995 82397..83572 + 1176 WP_044458673.1 ATP-binding protein -
UC34_RS25000 83860..84153 - 294 WP_044458674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
UC34_RS25005 84141..84413 - 273 WP_044458675.1 CopG family ribbon-helix-helix protein Antitoxin
UC34_RS25010 84579..85151 + 573 Protein_83 recombinase family protein -
UC34_RS25015 85290..86189 - 900 WP_044458676.1 HTH-type transcriptional regulator ArgP -
UC34_RS25020 86339..87400 - 1062 WP_157123394.1 hypothetical protein -
UC34_RS25025 87616..88437 - 822 WP_044453167.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100282 100282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10652.26 Da        Isoelectric Point: 6.4566

>T53071 WP_044458674.1 NZ_CP010898:c84153-83860 [Pandoraea vervacti]
VPQVIVTEGAAQGLERCRRFLAVKAPDAAKRAGQAIERQFLLLETAPDIGRPFPEMPELRELVIAFGDSGYVAVYRHEAA
ADAVYILAFRHQKEAGC

Download         Length: 294 bp

>T53071 NZ_CP010898:c84153-83860 [Pandoraea vervacti]
GTGCCACAAGTAATCGTCACTGAGGGCGCGGCGCAGGGCTTGGAGCGATGTCGCCGCTTCCTTGCCGTTAAGGCCCCAGA
TGCTGCCAAGCGCGCGGGTCAGGCCATCGAGCGGCAATTCCTGCTGCTGGAAACAGCTCCTGACATTGGTCGTCCATTCC
CCGAAATGCCGGAGCTGCGCGAACTTGTGATTGCCTTCGGCGATTCCGGCTATGTCGCCGTGTACCGCCACGAGGCGGCT
GCCGATGCGGTCTACATCCTAGCATTCCGACACCAGAAAGAAGCGGGTTGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10575.82 Da        Isoelectric Point: 6.9788

>AT53071 WP_044458675.1 NZ_CP010898:c84413-84141 [Pandoraea vervacti]
MATSLKIDDSLKGRVHQLATQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYQETGRHLTGQEVRTWLNTWGTE
HETTVPECHK

Download         Length: 273 bp

>AT53071 NZ_CP010898:c84413-84141 [Pandoraea vervacti]
ATGGCAACATCGCTCAAAATCGACGATTCGCTGAAAGGTCGCGTCCACCAGCTCGCTACCCAGCGCCGTCGCTCACCCCA
CTGGATCATGCTGGAGGCCATCCAGCAGTACGTCGAGCGTGAGGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCAT
CGTGGGCGGCTTATCAGGAAACCGGTCGGCACCTGACAGGCCAAGAGGTTCGCACCTGGTTAAACACCTGGGGCACGGAA
CATGAAACGACGGTGCCTGAGTGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5KJQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5JXW2

References