Detailed information of TA system TA053070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 4623798..4625091
• Replicon: chromosome
• Accession: NZ_CP010897
• Organism: Pandoraea vervacti strain NS15

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1J0LY00
• Locus tag: UC34_RS20090
• Protein ID: WP_044456927.1
• Coordinates: 4623798..4624418 (-)
• Length: 207 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: UC34_RS20095
• Protein ID: WP_044456928.1
• Coordinates: 4624531..4625091 (-)
• Length: 187 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UC34_RS20070	4620088..4620834	+	747	WP_044458469.1	FadR family transcriptional regulator	-
UC34_RS20075	4620917..4621534	-	618	WP_052811144.1	pyridoxamine 5'-phosphate oxidase family protein	-
UC34_RS20080	4621657..4622463	+	807	WP_157123374.1	helix-turn-helix transcriptional regulator	-
UC34_RS20085	4622678..4623640	+	963	WP_044458472.1	dipeptidyl aminopeptidase	-
UC34_RS20090	4623798..4624418	-	621	WP_044456927.1	HD domain-containing protein	Toxin
UC34_RS20095	4624531..4625091	-	561	WP_044456928.1	helix-turn-helix domain-containing protein	Antitoxin
UC34_RS20105	4625340..4626907	+	1568	WP_157123100.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD/PDEase domain (34-140)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-60)

Sequences

Toxin

Protein

• Length: 207 a.a.
• Molecular weight: 23468.36 Da
• Isoelectric Point: 5.7024

>T53070 WP_044456927.1 NZ_CP010897:c4624418-4623798 [Pandoraea vervacti]
MNAATMDGRLNFLRTCERLKDVLRSARTSSGRRESTAEHSWRLALMATVFMDQLGDVDRLRILELCLVHDLGEALHGDVP
APEQTRDTDKDAIERRDLLEVCAPLDSPLREKIVALWDEYSQAKTPEARAVKALDKLETLLQHTQGDNPPDFDYTFNLDY
GRKYTDAMPPLRAIRARIDEATRERRERQAHAEPARAVNSGQNQSQ

Nucleotide

• Length: 621 bp

>T53070 NZ_CP010897:c4624418-4623798 [Pandoraea vervacti]
ATGAATGCAGCGACGATGGATGGCCGGTTGAATTTCCTGCGAACCTGCGAGCGGTTGAAGGACGTGCTGCGAAGTGCGCG
TACCTCGTCGGGACGTCGCGAAAGCACCGCCGAGCACAGTTGGCGACTCGCGCTCATGGCGACCGTCTTCATGGACCAGT
TGGGCGACGTCGACCGGCTGCGGATCCTGGAGCTCTGCCTCGTTCACGATCTCGGTGAAGCGCTCCACGGCGACGTGCCC
GCCCCCGAACAGACCCGAGACACCGACAAAGACGCCATCGAGCGCCGCGATCTTCTCGAAGTTTGCGCGCCGCTCGATTC
GCCACTGCGAGAGAAGATCGTCGCGTTGTGGGACGAGTACTCGCAAGCCAAAACGCCGGAGGCCCGGGCCGTCAAGGCAT
TGGACAAGCTCGAAACCCTGCTGCAACACACGCAAGGCGATAACCCGCCGGATTTCGACTACACGTTCAATCTCGACTAC
GGACGAAAGTACACCGACGCGATGCCGCCGCTTCGCGCGATACGCGCACGGATCGACGAGGCGACGCGCGAGCGCAGGGA
ACGTCAGGCACACGCCGAGCCGGCGCGCGCGGTGAATTCCGGGCAGAACCAATCGCAGTGA

Antitoxin

Protein

• Length: 187 a.a.
• Molecular weight: 20253.12 Da
• Isoelectric Point: 8.8330

>AT53070 WP_044456928.1 NZ_CP010897:c4625091-4624531 [Pandoraea vervacti]
MVATTTPQLPFAASSALRRWRTLRRIKQSHAAQLLGVSQSTVSRWEAGTLTIGGDELARIEPLLAAHLDSPADGALARLV
NFNALPMHLVCDLTHRLLACSPSRAVEFSAPVSTLLGRSLWPFATEAIQTQEAFLRSAGWGERAAQSVEFETGSNASTLV
PIRDSRCRWTRFTLSDGTVARLVETL

Nucleotide

• Length: 561 bp

>AT53070 NZ_CP010897:c4625091-4624531 [Pandoraea vervacti]
ATGGTCGCGACCACCACCCCCCAACTGCCGTTCGCCGCGTCATCCGCATTGCGACGCTGGCGCACGTTGCGGCGTATCAA
GCAATCGCACGCGGCCCAGTTGCTGGGCGTCTCGCAATCCACAGTGTCGCGGTGGGAGGCGGGCACGCTGACGATTGGCG
GGGACGAACTCGCCCGCATCGAGCCTTTGCTGGCGGCGCATCTCGACTCGCCAGCGGACGGCGCGCTGGCGCGTCTCGTC
AATTTCAACGCGTTGCCGATGCATCTCGTTTGTGACCTGACACATCGATTGCTCGCATGTTCGCCCTCACGGGCGGTCGA
ATTTTCCGCGCCTGTGTCCACGCTGCTCGGCAGGTCGTTGTGGCCTTTTGCGACCGAAGCCATTCAAACCCAGGAAGCTT
TCCTCAGATCTGCCGGATGGGGCGAGCGCGCCGCACAGTCCGTCGAGTTCGAGACAGGTAGCAATGCGTCGACACTCGTG
CCGATTCGGGACAGCCGCTGCCGATGGACCCGCTTCACACTCTCCGACGGAACTGTCGCGCGCCTTGTGGAAACGCTTTG
A

Structures

Toxin

• AlphaFold DB: A0A1J0LY00