Detailed information of TA system TA053069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3223918..3224525
• Replicon: chromosome
• Accession: NZ_CP010897
• Organism: Pandoraea vervacti strain NS15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: UC34_RS14140
• Protein ID: WP_052811053.1
• Coordinates: 3223918..3224226 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C5JZW3
• Locus tag: UC34_RS14145
• Protein ID: WP_044456054.1
• Coordinates: 3224223..3224525 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UC34_RS14110	3218954..3219811	+	858	WP_044456050.1	AraC family transcriptional regulator	-
UC34_RS14115	3219981..3220166	-	186	WP_044456051.1	hypothetical protein	-
UC34_RS14125	3221411..3221899	+	489	WP_084070255.1	IS66 family insertion sequence hypothetical protein	-
UC34_RS14130	3221896..3222243	+	348	WP_044453173.1	IS66 family insertion sequence element accessory protein TnpB	-
UC34_RS14135	3222302..3223888	+	1587	WP_044453172.1	IS66 family transposase	-
UC34_RS14140	3223918..3224226	+	309	WP_052811053.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UC34_RS14145	3224223..3224525	+	303	WP_044456054.1	putative addiction module antidote protein	Antitoxin
UC34_RS25190	3224537..3225455	-	919	Protein_2773	tyrosine-type recombinase/integrase	-
UC34_RS14160	3226048..3226923	+	876	WP_044456055.1	presqualene diphosphate synthase HpnD	-
UC34_RS14165	3227174..3228400	-	1227	WP_044458188.1	DUF1501 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (7-93)

Antitoxin

• Uncharacterized protein HI1420 (3-97)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11507.19 Da
• Isoelectric Point: 10.6561

>T53069 WP_052811053.1 NZ_CP010897:3223918-3224226 [Pandoraea vervacti]
IYGTHRALTFRTWLGKLKDVTGRAKIALRIRRAEAGNFGDSKSLGGGLWEMRIDHGPGYRVYYGRDGEITYLLVCGGGKS
TQQADIARARDFWNKVRMESLK

Nucleotide

• Length: 309 bp

>T53069 NZ_CP010897:3223918-3224226 [Pandoraea vervacti]
ATCTACGGTACACATCGAGCGCTTACGTTTCGAACGTGGCTTGGTAAGCTGAAAGATGTAACGGGCAGAGCCAAGATCGC
GCTGCGCATTAGGCGCGCCGAGGCCGGGAACTTTGGAGACTCCAAGTCGCTCGGCGGTGGTCTGTGGGAAATGCGCATCG
ACCACGGGCCGGGATACCGCGTGTACTACGGTAGAGATGGCGAAATCACTTACTTGCTGGTTTGCGGAGGCGGCAAGTCA
ACCCAACAGGCGGACATTGCTCGCGCCCGGGATTTTTGGAACAAGGTCCGCATGGAGTCGCTGAAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10767.26 Da
• Isoelectric Point: 5.0622

>AT53069 WP_044456054.1 NZ_CP010897:3224223-3224525 [Pandoraea vervacti]
MSRTDITRFDASEYLDSDEMIAEYLNAALEENDPALFLSAIADVAKAKGMTQVALAAGLGRESLYKALSPNAQPRFSTVL
RVMHALGVKLSTVPDRAAHA

Nucleotide

• Length: 303 bp

>AT53069 NZ_CP010897:3224223-3224525 [Pandoraea vervacti]
ATGAGTAGAACAGACATCACTCGGTTTGACGCGTCGGAGTATCTCGATAGCGATGAAATGATCGCCGAGTACCTCAACGC
GGCGCTTGAAGAGAATGACCCAGCGCTTTTTCTATCCGCGATTGCCGATGTGGCCAAGGCGAAAGGCATGACGCAGGTGG
CACTAGCCGCCGGCCTTGGTCGAGAGAGTTTGTACAAGGCGCTATCACCCAATGCTCAACCCCGATTCTCCACAGTATTG
CGAGTCATGCACGCGCTAGGCGTAAAGCTTTCGACAGTCCCTGACCGCGCGGCGCACGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A0C5JZW3