Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 6287246..6287934 Replicon chromosome
Accession NZ_CP010892
Organism Pseudomonas sp. MRSN12121

Toxin (Protein)


Gene name hicA Uniprot ID A0A0C5ECJ4
Locus tag TO66_RS28725 Protein ID WP_044465417.1
Coordinates 6287246..6287428 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0C5ESH8
Locus tag TO66_RS28730 Protein ID WP_044465418.1
Coordinates 6287500..6287934 (+) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TO66_RS28695 6282614..6283321 + 708 WP_044465411.1 hypothetical protein -
TO66_RS28700 6283318..6284232 + 915 WP_044465412.1 hypothetical protein -
TO66_RS28705 6284229..6284756 + 528 WP_044465413.1 hypothetical protein -
TO66_RS28710 6284763..6285467 + 705 WP_044465414.1 hypothetical protein -
TO66_RS28715 6285440..6286384 + 945 WP_044465415.1 hypothetical protein -
TO66_RS28720 6286381..6287022 - 642 WP_044465416.1 hypothetical protein -
TO66_RS28725 6287246..6287428 + 183 WP_044465417.1 type II toxin-antitoxin system HicA family toxin Toxin
TO66_RS28730 6287500..6287934 + 435 WP_044465418.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TO66_RS28735 6288480..6288728 + 249 WP_044465419.1 hypothetical protein -
TO66_RS28740 6289321..6289959 + 639 WP_082061182.1 lipopolysaccharide biosynthesis protein -
TO66_RS28745 6290031..6292385 - 2355 WP_044465421.1 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 6224928..6287934 63006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6751.84 Da        Isoelectric Point: 10.9086

>T53065 WP_044465417.1 NZ_CP010892:6287246-6287428 [Pseudomonas sp. MRSN12121]
MKYSEFRRWLKAQGVQFQAGKGSHFKVSLNGKSTVFPDHGAKEMGEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T53065 NZ_CP010892:6287246-6287428 [Pseudomonas sp. MRSN12121]
ATGAAGTACAGCGAGTTTCGGCGATGGTTGAAGGCCCAAGGCGTTCAGTTTCAGGCCGGTAAGGGTAGCCACTTCAAGGT
TTCACTGAATGGCAAATCAACCGTATTTCCAGACCACGGAGCCAAGGAAATGGGCGAAGGGTTGAGAAAGTCGATAATCA
AACAGCTGGGCCTCAAGGACTGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15871.13 Da        Isoelectric Point: 5.6090

>AT53065 WP_044465418.1 NZ_CP010892:6287500-6287934 [Pseudomonas sp. MRSN12121]
MFEYALEIHKEPGSFWLSCAEIPEMHAAGETLDEALDSALDSIETALSIYVDDRRAIPTGGGKRAAGHAVLRLPALTAAK
IALWNTLLESGVSKAELARRLDVNRPQVDRLVDFLHHSKIENVERALQQLGRRISLSVEKMEAA

Download         Length: 435 bp

>AT53065 NZ_CP010892:6287500-6287934 [Pseudomonas sp. MRSN12121]
ATGTTTGAGTATGCGTTAGAGATTCACAAAGAGCCGGGCAGCTTTTGGCTGTCGTGTGCAGAAATTCCAGAGATGCACGC
CGCCGGTGAAACTCTGGACGAAGCGTTGGACAGCGCACTGGATTCAATCGAGACAGCTTTGTCTATTTATGTCGATGATC
GTCGGGCTATTCCAACTGGTGGAGGGAAGAGAGCAGCGGGCCACGCCGTGTTGCGTCTGCCAGCTCTCACTGCGGCGAAA
ATCGCATTGTGGAATACGCTCCTGGAGTCGGGAGTGAGTAAAGCCGAGTTGGCCCGTCGCTTGGATGTTAATAGGCCCCA
GGTTGATCGCCTGGTCGACTTTCTTCATCACTCCAAAATCGAAAACGTTGAGCGCGCACTGCAGCAACTCGGGCGCCGTA
TCTCGCTTTCAGTGGAAAAGATGGAAGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5ECJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5ESH8

References