53061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2409093..2409712 Replicon chromosome
Accession NZ_CP010892
Organism Pseudomonas sp. MRSN12121

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag TO66_RS11170 Protein ID WP_009048155.1
Coordinates 2409530..2409712 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0C5E0F1
Locus tag TO66_RS11165 Protein ID WP_044462357.1
Coordinates 2409093..2409494 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TO66_RS11140 2404219..2404815 - 597 WP_044462352.1 TetR/AcrR family transcriptional regulator -
TO66_RS11145 2404808..2405659 - 852 WP_044462353.1 3-hydroxybutyryl-CoA dehydrogenase -
TO66_RS11150 2405830..2406843 + 1014 WP_044462354.1 AraC family transcriptional regulator -
TO66_RS11155 2406868..2407491 - 624 WP_044462355.1 HAD family phosphatase -
TO66_RS11160 2407730..2408488 + 759 WP_044462356.1 hypothetical protein -
TO66_RS11165 2409093..2409494 - 402 WP_044462357.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TO66_RS11170 2409530..2409712 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
TO66_RS11175 2409871..2410152 - 282 WP_044462358.1 hypothetical protein -
TO66_RS11180 2410676..2411704 + 1029 WP_177330396.1 DUF4263 domain-containing protein -
TO66_RS11185 2411852..2412400 - 549 WP_044462360.1 hypothetical protein -
TO66_RS11190 2412551..2413213 + 663 WP_044462361.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2319313..2424617 105304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T53061 WP_009048155.1 NZ_CP010892:c2409712-2409530 [Pseudomonas sp. MRSN12121]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T53061 NZ_CP010892:c2409712-2409530 [Pseudomonas sp. MRSN12121]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTAACCGGCAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14603.61 Da        Isoelectric Point: 4.9136

>AT53061 WP_044462357.1 NZ_CP010892:c2409494-2409093 [Pseudomonas sp. MRSN12121]
VQYPICIEWGNEHTATGIQIPDIPGAVTAGDSFEAAYSAAIEIAHLMLEELAREGHAIPLPTSIGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT53061 NZ_CP010892:c2409494-2409093 [Pseudomonas sp. MRSN12121]
GTGCAATATCCCATCTGCATCGAGTGGGGCAACGAACACACGGCCACCGGCATCCAGATTCCCGACATTCCCGGAGCTGT
CACCGCCGGCGACAGCTTCGAGGCTGCGTACAGCGCCGCCATCGAGATCGCGCACCTCATGCTCGAAGAGCTGGCCCGCG
AGGGGCATGCCATTCCCCTGCCCACCTCCATCGGCACGCACCGCGCCAATCCCGATTTCGAGGGCATGGGCTGGGGCATG
CTGGATATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCCTGCCGGGTTACGTGATCCAGCGGAT
CGACCGCTTTGTCCGGGAGCACAACATCAAGAGCCGGTCGTCGTTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5E0F1

References