53059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1536501..1537014 Replicon chromosome
Accession NZ_CP010892
Organism Pseudomonas sp. MRSN12121

Toxin (Protein)


Gene name relE Uniprot ID A0A0C5DT10
Locus tag TO66_RS06955 Protein ID WP_044461640.1
Coordinates 1536501..1536785 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C5DY45
Locus tag TO66_RS06960 Protein ID WP_044461641.1
Coordinates 1536775..1537014 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TO66_RS06935 1532240..1533022 - 783 WP_044461636.1 aldolase -
TO66_RS06940 1533183..1533725 + 543 WP_044461637.1 XRE family transcriptional regulator -
TO66_RS06945 1534047..1535066 - 1020 WP_044461638.1 DUF4917 family protein -
TO66_RS06950 1535224..1536372 + 1149 WP_044461639.1 L-threonine dehydrogenase -
TO66_RS06955 1536501..1536785 - 285 WP_044461640.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TO66_RS06960 1536775..1537014 - 240 WP_044461641.1 CopG family ribbon-helix-helix protein Antitoxin
TO66_RS06965 1537150..1537566 + 417 WP_044461642.1 fosfomycin resistance glutathione transferase -
TO66_RS06970 1537694..1538335 + 642 WP_044461643.1 LysE family translocator -
TO66_RS06975 1538444..1539784 + 1341 WP_044461644.1 sensor domain-containing diguanylate cyclase -
TO66_RS06980 1539922..1540446 + 525 WP_044461645.1 DUF4142 domain-containing protein -
TO66_RS06985 1540518..1540922 - 405 WP_044461646.1 low affinity iron permease family protein -
TO66_RS06990 1541042..1541575 - 534 WP_044461647.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10796.42 Da        Isoelectric Point: 10.6946

>T53059 WP_044461640.1 NZ_CP010892:c1536785-1536501 [Pseudomonas sp. MRSN12121]
MHVEWLRTALKNLDDEAAYIAQDSPQAAAEFVTAILSSIQHLAHFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGW

Download         Length: 285 bp

>T53059 NZ_CP010892:c1536785-1536501 [Pseudomonas sp. MRSN12121]
ATGCACGTTGAGTGGCTGCGTACCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAAGACAGTCCTCAGGC
CGCCGCGGAATTCGTCACAGCCATCCTGAGCAGTATTCAACACCTGGCCCATTTTCCTGCCAGTGGGCGCGAAGGTCGCC
TGCCCGGTACCCGAGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCATACCCGGCGCTTGCCGCCTGCCGGATGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8677.76 Da        Isoelectric Point: 4.4217

>AT53059 WP_044461641.1 NZ_CP010892:c1537014-1536775 [Pseudomonas sp. MRSN12121]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQIDEIQKALTEAEAGDFVSAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT53059 NZ_CP010892:c1537014-1536775 [Pseudomonas sp. MRSN12121]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCCCTGAGAGAATATCTGGCCCGTGAAGCCTGGCAAATCGACGAGATTCAGAAAGCCCTGA
CTGAAGCAGAAGCAGGCGACTTCGTCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5DT10

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5DY45

References