Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 312151..312764 Replicon chromosome
Accession NZ_CP010892
Organism Pseudomonas sp. MRSN12121

Toxin (Protein)


Gene name hicA Uniprot ID A0A0C5ED99
Locus tag TO66_RS01360 Protein ID WP_044460628.1
Coordinates 312151..312333 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0C5EE99
Locus tag TO66_RS01365 Protein ID WP_044465918.1
Coordinates 312363..312764 (+) Length 134 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TO66_RS01340 307766..309730 + 1965 WP_171820145.1 choline transporter BetT -
TO66_RS01345 309836..310093 - 258 WP_044460625.1 hypothetical protein -
TO66_RS01350 310253..310993 - 741 WP_044460626.1 SDR family oxidoreductase -
TO66_RS01355 311133..312023 + 891 WP_044460627.1 LysR family transcriptional regulator -
TO66_RS01360 312151..312333 + 183 WP_044460628.1 type II toxin-antitoxin system HicA family toxin Toxin
TO66_RS01365 312363..312764 + 402 WP_044465918.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TO66_RS01370 312774..313820 - 1047 WP_044460629.1 LacI family DNA-binding transcriptional regulator -
TO66_RS01375 314029..316287 + 2259 WP_044460630.1 TonB-dependent receptor -
TO66_RS01380 316334..317686 + 1353 WP_044460631.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 7018.16 Da        Isoelectric Point: 10.0476

>T53057 WP_044460628.1 NZ_CP010892:312151-312333 [Pseudomonas sp. MRSN12121]
MRSRELIRMIEEDGWYLIAVKGSHHQYRHQYKPGRVTVPHPEADLPRGTIHCILKQAGLK

Download         Length: 183 bp

>T53057 NZ_CP010892:312151-312333 [Pseudomonas sp. MRSN12121]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAGGGCAGCCATCACCAATA
CAGGCATCAGTACAAGCCGGGGCGGGTTACCGTGCCTCACCCGGAGGCGGATCTGCCCCGGGGCACGATCCACTGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14717.53 Da        Isoelectric Point: 4.6438

>AT53057 WP_044465918.1 NZ_CP010892:312363-312764 [Pseudomonas sp. MRSN12121]
MKFPVVLHKDADSEYGVIVPDVPGCFSAGRTAAQAFENVKEALSLHYEGLVADGEPLPQVHEIDEHIDNPDYAGGVWGVV
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT53057 NZ_CP010892:312363-312764 [Pseudomonas sp. MRSN12121]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGAATACGGCGTGATTGTCCCTGATGTGCCGGGCTGTTTTTC
CGCGGGACGCACTGCGGCGCAAGCCTTCGAGAACGTGAAGGAAGCCCTGTCGCTGCACTATGAAGGCCTGGTTGCCGATG
GCGAGCCGCTGCCCCAGGTGCACGAGATCGACGAGCATATCGACAATCCCGACTATGCCGGCGGAGTGTGGGGCGTGGTC
GAGTTCGACATCACGCCGTACTTCGGCAAGGCCGTGCGGTTCAACGCGACATTGCCAGAGCAACTGCTGGAGCGCATCGA
CCAGACGGTCAAGCGCGACCAGCGCTATCGCTCGCGCTCGGGCTTCCTCGCCGCGGCGGCATTGCGCGAATTGTCCGCGT
AG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0C5ED99


Antitoxin

Source ID Structure
AlphaFold DB A0A0C5EE99

References