Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 312151..312764 | Replicon | chromosome |
Accession | NZ_CP010892 | ||
Organism | Pseudomonas sp. MRSN12121 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0C5ED99 |
Locus tag | TO66_RS01360 | Protein ID | WP_044460628.1 |
Coordinates | 312151..312333 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A0C5EE99 |
Locus tag | TO66_RS01365 | Protein ID | WP_044465918.1 |
Coordinates | 312363..312764 (+) | Length | 134 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
TO66_RS01340 | 307766..309730 | + | 1965 | WP_171820145.1 | choline transporter BetT | - |
TO66_RS01345 | 309836..310093 | - | 258 | WP_044460625.1 | hypothetical protein | - |
TO66_RS01350 | 310253..310993 | - | 741 | WP_044460626.1 | SDR family oxidoreductase | - |
TO66_RS01355 | 311133..312023 | + | 891 | WP_044460627.1 | LysR family transcriptional regulator | - |
TO66_RS01360 | 312151..312333 | + | 183 | WP_044460628.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
TO66_RS01365 | 312363..312764 | + | 402 | WP_044465918.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
TO66_RS01370 | 312774..313820 | - | 1047 | WP_044460629.1 | LacI family DNA-binding transcriptional regulator | - |
TO66_RS01375 | 314029..316287 | + | 2259 | WP_044460630.1 | TonB-dependent receptor | - |
TO66_RS01380 | 316334..317686 | + | 1353 | WP_044460631.1 | LLM class flavin-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 7018.16 Da Isoelectric Point: 10.0476
>T53057 WP_044460628.1 NZ_CP010892:312151-312333 [Pseudomonas sp. MRSN12121]
MRSRELIRMIEEDGWYLIAVKGSHHQYRHQYKPGRVTVPHPEADLPRGTIHCILKQAGLK
MRSRELIRMIEEDGWYLIAVKGSHHQYRHQYKPGRVTVPHPEADLPRGTIHCILKQAGLK
Download Length: 183 bp
>T53057 NZ_CP010892:312151-312333 [Pseudomonas sp. MRSN12121]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAGGGCAGCCATCACCAATA
CAGGCATCAGTACAAGCCGGGGCGGGTTACCGTGCCTCACCCGGAGGCGGATCTGCCCCGGGGCACGATCCACTGCATCT
TGAAACAGGCGGGCCTGAAATGA
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAGGGCAGCCATCACCAATA
CAGGCATCAGTACAAGCCGGGGCGGGTTACCGTGCCTCACCCGGAGGCGGATCTGCCCCGGGGCACGATCCACTGCATCT
TGAAACAGGCGGGCCTGAAATGA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14717.53 Da Isoelectric Point: 4.6438
>AT53057 WP_044465918.1 NZ_CP010892:312363-312764 [Pseudomonas sp. MRSN12121]
MKFPVVLHKDADSEYGVIVPDVPGCFSAGRTAAQAFENVKEALSLHYEGLVADGEPLPQVHEIDEHIDNPDYAGGVWGVV
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA
MKFPVVLHKDADSEYGVIVPDVPGCFSAGRTAAQAFENVKEALSLHYEGLVADGEPLPQVHEIDEHIDNPDYAGGVWGVV
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA
Download Length: 402 bp
>AT53057 NZ_CP010892:312363-312764 [Pseudomonas sp. MRSN12121]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGAATACGGCGTGATTGTCCCTGATGTGCCGGGCTGTTTTTC
CGCGGGACGCACTGCGGCGCAAGCCTTCGAGAACGTGAAGGAAGCCCTGTCGCTGCACTATGAAGGCCTGGTTGCCGATG
GCGAGCCGCTGCCCCAGGTGCACGAGATCGACGAGCATATCGACAATCCCGACTATGCCGGCGGAGTGTGGGGCGTGGTC
GAGTTCGACATCACGCCGTACTTCGGCAAGGCCGTGCGGTTCAACGCGACATTGCCAGAGCAACTGCTGGAGCGCATCGA
CCAGACGGTCAAGCGCGACCAGCGCTATCGCTCGCGCTCGGGCTTCCTCGCCGCGGCGGCATTGCGCGAATTGTCCGCGT
AG
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGAATACGGCGTGATTGTCCCTGATGTGCCGGGCTGTTTTTC
CGCGGGACGCACTGCGGCGCAAGCCTTCGAGAACGTGAAGGAAGCCCTGTCGCTGCACTATGAAGGCCTGGTTGCCGATG
GCGAGCCGCTGCCCCAGGTGCACGAGATCGACGAGCATATCGACAATCCCGACTATGCCGGCGGAGTGTGGGGCGTGGTC
GAGTTCGACATCACGCCGTACTTCGGCAAGGCCGTGCGGTTCAACGCGACATTGCCAGAGCAACTGCTGGAGCGCATCGA
CCAGACGGTCAAGCGCGACCAGCGCTATCGCTCGCGCTCGGGCTTCCTCGCCGCGGCGGCATTGCGCGAATTGTCCGCGT
AG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C5ED99 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C5EE99 |