Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 13197..13744 Replicon plasmid P2
Accession NZ_CP010886
Organism Vibrio parahaemolyticus strain CHN25

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag vpachn25_RS24535 Protein ID WP_065871640.1
Coordinates 13442..13744 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag vpachn25_RS24530 Protein ID WP_065871639.1
Coordinates 13197..13454 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
vpachn25_RS24495 8359..8850 + 492 WP_025640120.1 RDD family protein -
vpachn25_RS24500 9033..9779 + 747 WP_065871634.1 hypothetical protein -
vpachn25_RS24505 9957..10430 + 474 WP_065871635.1 GNAT family N-acetyltransferase -
vpachn25_RS26060 10459..10536 + 78 WP_079853708.1 DUF3265 domain-containing protein -
vpachn25_RS24510 10565..11335 + 771 WP_065871636.1 DUF2971 domain-containing protein -
vpachn25_RS26065 11350..11442 + 93 WP_072612521.1 DUF3265 domain-containing protein -
vpachn25_RS24515 11468..12004 + 537 WP_065871637.1 nucleotidyltransferase family protein -
vpachn25_RS24520 12141..12416 + 276 WP_065871638.1 antibiotic biosynthesis monooxygenase -
vpachn25_RS26070 12429..12530 + 102 WP_079880029.1 DUF3265 domain-containing protein -
vpachn25_RS24525 12558..12992 + 435 WP_029823813.1 GNAT family N-acetyltransferase -
vpachn25_RS24530 13197..13454 + 258 WP_065871639.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
vpachn25_RS24535 13442..13744 + 303 WP_065871640.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
vpachn25_RS26075 13780..13872 + 93 WP_079880017.1 DUF3265 domain-containing protein -
vpachn25_RS24540 13912..14214 + 303 WP_065871641.1 hypothetical protein -
vpachn25_RS24545 14374..14781 + 408 WP_025523877.1 OsmC family protein -
vpachn25_RS24550 14931..15530 + 600 WP_065871642.1 hypothetical protein -
vpachn25_RS27180 15881..16048 + 168 WP_162780957.1 DUF3265 domain-containing protein -
vpachn25_RS26085 17041..17130 + 90 WP_074190212.1 DUF3265 domain-containing protein -
vpachn25_RS24565 17163..17705 + 543 WP_065871644.1 GNAT family N-acetyltransferase -
vpachn25_RS26090 17734..17823 + 90 WP_079880019.1 hypothetical protein -
vpachn25_RS24570 17845..18474 + 630 WP_065871645.1 hypothetical protein -
vpachn25_RS26095 18503..18581 + 79 Protein_38 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..83481 83481
- inside Integron - - 1..83465 83464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11640.53 Da        Isoelectric Point: 4.8951

>T53026 WP_065871640.1 NZ_CP010886:13442-13744 [Vibrio parahaemolyticus]
MAEIIWTEPALSDINDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T53026 NZ_CP010886:13442-13744 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCCGACATCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAACTAGAACATCTAAGCTATCGTGAAGTTGTAGTTAATCCGTGCCGCGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9548.06 Da        Isoelectric Point: 7.3177

>AT53026 WP_065871639.1 NZ_CP010886:13197-13454 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVEDYEFMQNRLAILEGIARGERALADGKVVSHDGAKDKM
SKWLK

Download         Length: 258 bp

>AT53026 NZ_CP010886:13197-13454 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAAATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGAAGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCGGACGGTAAAGTGGTGAGTCACGATGGAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References