Detailed information of TA system TA053013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4888827..4889647
• Replicon: chromosome
• Accession: NZ_CP010876
• Organism: Escherichia coli strain MNCRE44

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: SY51_RS24635
• Protein ID: WP_001054379.1
• Coordinates: 4888827..4889084 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: SY51_RS24640
• Protein ID: WP_000123957.1
• Coordinates: 4889096..4889647 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SY51_RS24620	4886689..4886943	-	255	WP_000788354.1	glycosyltransferase	-
SY51_RS29775	4887106..4888253	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
SY51_RS28890	4888286..4888450	+	165	Protein_4664	GNAT family N-acetyltransferase	-
SY51_RS24635	4888827..4889084	+	258	WP_001054379.1	YjhX family toxin	Toxin
SY51_RS24640	4889096..4889647	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
SY51_RS24645	4889699..4890445	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
SY51_RS24650	4890573..4890833	+	261	WP_000077645.1	hypothetical protein	-
SY51_RS31110	4890871..4890987	+	117	Protein_4669	VOC family protein	-
SY51_RS24655	4891232..4892353	+	1122	WP_000010833.1	M42 family metallopeptidase	-
SY51_RS24660	4892350..4892628	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
SY51_RS24665	4892640..4893953	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4863571..4897868	34297

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T53013 WP_001054379.1 NZ_CP010876:4888827-4889084 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T53013 NZ_CP010876:4888827-4889084 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT53013 WP_000123957.1 NZ_CP010876:4889096-4889647 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT53013 NZ_CP010876:4889096-4889647 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030