Detailed information of TA system TA052984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 256940..257552
• Replicon: chromosome
• Accession: NZ_CP010874
• Organism: Streptococcus agalactiae strain CU_GBS_08

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: CUGBS08_RS01530
• Protein ID: WP_000384860.1
• Coordinates: 256940..257275 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: CUGBS08_RS01535
• Protein ID: WP_000259017.1
• Coordinates: 257265..257552 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUGBS08_RS01500	252138..252779	+	642	WP_000591144.1	hypothetical protein	-
CUGBS08_RS01510	253079..253954	+	876	WP_000421240.1	hypothetical protein	-
CUGBS08_RS01515	253990..254424	+	435	WP_001220479.1	hypothetical protein	-
CUGBS08_RS01520	254741..255997	+	1257	WP_000122836.1	plasmid recombination protein	-
CUGBS08_RS01525	256165..256635	+	471	WP_000130119.1	hypothetical protein	-
CUGBS08_RS01530	256940..257275	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CUGBS08_RS01535	257265..257552	-	288	WP_000259017.1	hypothetical protein	Antitoxin
CUGBS08_RS01540	258059..258349	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
CUGBS08_RS01545	258451..258819	+	369	WP_001882138.1	hypothetical protein	-
CUGBS08_RS01550	258857..259417	+	561	WP_001865562.1	hypothetical protein	-
CUGBS08_RS01555	259390..260070	+	681	WP_001865565.1	hypothetical protein	-
CUGBS08_RS01560	260055..260441	+	387	WP_000259069.1	hypothetical protein	-
CUGBS08_RS01565	260475..260756	+	282	WP_017647916.1	hypothetical protein	-
CUGBS08_RS01580	261599..262459	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T52984 WP_000384860.1 NZ_CP010874:c257275-256940 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T52984 NZ_CP010874:c257275-256940 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT52984 WP_000259017.1 NZ_CP010874:c257552-257265 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT52984 NZ_CP010874:c257552-257265 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6