Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 49814..50426 Replicon plasmid pNS6001
Accession NZ_CP010870
Organism Confluentimicrobium sp. EMB200-NS6 strain EMBL200_NS6

Toxin (Protein)


Gene name vapC Uniprot ID A0A840CKU8
Locus tag TQ29_RS17945 Protein ID WP_012187367.1
Coordinates 50031..50426 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A840CLY7
Locus tag TQ29_RS17940 Protein ID WP_054540540.1
Coordinates 49814..50041 (+) Length 76 a.a.

Genomic Context

TQ29_RS17940TQ29_RS17945TQ29_RS17960TQ29_RS17965TQ29_RS17925TQ29_RS17930TQ29_RS17935TQ29_RS17950TQ29_RS17955TQ29_RS20425
Location: 49814..50041 (228 bp)
Type: Antitoxin
Protein ID: WP_054540540.1
Location: 50031..50426 (396 bp)
Type: Toxin
Protein ID: WP_012187367.1
Location: 52705..53595 (891 bp)
Type: Others
Protein ID: WP_054540542.1
Location: 53598..54197 (600 bp)
Type: Others
Protein ID: WP_054540543.1
Location: 45887..47122 (1236 bp)
Type: Others
Protein ID: WP_012187363.1
Location: 47300..48316 (1017 bp)
Type: Others
Protein ID: WP_054540539.1
Location: 48313..49500 (1188 bp)
Type: Others
Protein ID: WP_027263652.1
Location: 50410..51306 (897 bp)
Type: Others
Protein ID: WP_054540541.1
Location: 51439..52425 (987 bp)
Type: Others
Protein ID: WP_139211443.1
Location: 54181..55215 (1035 bp)
Type: Others
Protein ID: WP_082386774.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
TQ29_RS1792545887..47122-1236WP_012187363.1replication initiation protein RepC-
TQ29_RS1793047300..48316-1017WP_054540539.1plasmid partitioning protein RepB-
TQ29_RS1793548313..49500-1188WP_027263652.1plasmid partitioning protein RepA-
TQ29_RS1794049814..50041+228WP_054540540.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
TQ29_RS1794550031..50426+396WP_012187367.1PIN domain-containing proteinToxin
TQ29_RS1795050410..51306-897WP_054540541.1recombinase family protein-
TQ29_RS1795551439..52425-987WP_139211443.1tyrosine-type recombinase/integrase-
TQ29_RS1796052705..53595+891WP_054540542.1DUF1403 family protein-
TQ29_RS1796553598..54197+600WP_054540543.1SMC-Scp complex subunit ScpB-
TQ29_RS2042554181..55215-1035WP_082386774.1TniQ family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..184737184737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-42)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14296.32 Da        Isoelectric Point: 4.2692

>T52983 WP_012187367.1 NZ_CP010870:50031-50426 [Confluentimicrobium sp. EMB200-NS6]
MSAEFADTNVVLYLLDDGPKAERAEEILGQGPRISVQVLNEAMVNCRRKAGLSWEDTGAFLEGITSVCPVEGLTVQTHQV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWTEDMHDGLLVEDRLRIVNPFA

Download         Length: 396 bp

>T52983 NZ_CP010870:50031-50426 [Confluentimicrobium sp. EMB200-NS6]
ATGAGCGCTGAATTCGCAGACACGAATGTTGTGCTCTACCTGCTCGACGATGGTCCAAAGGCTGAGAGGGCGGAGGAAAT
TCTGGGGCAGGGACCCCGGATCAGCGTTCAGGTCCTGAACGAAGCGATGGTCAATTGCCGACGGAAAGCTGGGCTCAGTT
GGGAAGATACCGGAGCGTTTCTTGAGGGTATTACGTCCGTATGCCCTGTCGAGGGCCTAACGGTTCAAACCCATCAAGTC
GGTCGCGCGTTGGCAGAGAAGTACCAGTTATCGGTCTATGACGCGATGATCGTGTCTGCCGCGCTGATCGCTGGGTGCAC
GACTTTGTGGACTGAGGACATGCACGACGGATTGCTGGTCGAGGATCGGCTGCGCATCGTCAATCCATTTGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8603.91 Da        Isoelectric Point: 11.1585

>AT52983 WP_054540540.1 NZ_CP010870:49814-50041 [Confluentimicrobium sp. EMB200-NS6]
MQVAKWGNSLAVRLPADLVRELGLKEGDQVDLVKDDGTILVRRQTRADEVLQGLRRFRRKLPKDARLSRDAAHER

Download         Length: 228 bp

>AT52983 NZ_CP010870:49814-50041 [Confluentimicrobium sp. EMB200-NS6]
ATGCAAGTTGCCAAATGGGGAAACTCCCTTGCCGTCCGGCTACCCGCGGATCTTGTGAGGGAACTCGGCTTAAAGGAAGG
CGATCAGGTCGACCTGGTAAAGGACGATGGAACCATTCTTGTGAGACGCCAAACTCGCGCCGATGAAGTTCTACAAGGGC
TGAGGCGGTTTCGCAGAAAACTGCCCAAGGATGCGCGTCTAAGCCGCGACGCCGCGCATGAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A840CKU8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A840CLY7

References