Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2036631..2037255 Replicon chromosome
Accession NZ_CP010867
Organism Streptococcus agalactiae strain SS1

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag RDF_RS10215 Protein ID WP_000253103.1
Coordinates 2036631..2036978 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag RDF_RS10220 Protein ID WP_000543070.1
Coordinates 2036968..2037255 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RDF_RS10195 2032346..2032702 - 357 WP_000105934.1 DUF1304 domain-containing protein -
RDF_RS10200 2032769..2035087 - 2319 WP_000883414.1 YhgE/Pip domain-containing protein -
RDF_RS10205 2035226..2035765 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
RDF_RS10210 2035851..2036147 - 297 WP_001052249.1 DUF4298 domain-containing protein -
RDF_RS10215 2036631..2036978 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RDF_RS10220 2036968..2037255 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RDF_RS10225 2037324..2037701 - 378 WP_000038826.1 DUF1492 domain-containing protein -
RDF_RS11235 2037676..2037828 - 153 Protein_1948 DUF1492 domain-containing protein -
RDF_RS10230 2037835..2038323 - 489 WP_000891151.1 hypothetical protein -
RDF_RS10235 2038396..2038953 - 558 WP_001258765.1 hypothetical protein -
RDF_RS11080 2039111..2039284 - 174 WP_000694573.1 hypothetical protein -
RDF_RS10245 2039281..2039538 - 258 WP_001069293.1 hypothetical protein -
RDF_RS10250 2039831..2041225 - 1395 WP_000656430.1 hypothetical protein -
RDF_RS10255 2041237..2042094 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T52982 WP_000253103.1 NZ_CP010867:c2036978-2036631 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T52982 NZ_CP010867:c2036978-2036631 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT52982 WP_000543070.1 NZ_CP010867:c2037255-2036968 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT52982 NZ_CP010867:c2037255-2036968 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References