Detailed information of TA system TA052957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 4224088..4225607
• Replicon: chromosome
• Accession: NZ_CP010836
• Organism: Sphingomonas hengshuiensis strain WHSC-8 isolate soil of Hengshui Lake

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: TS85_RS19135
• Protein ID: WP_044334351.1
• Coordinates: 4224693..4225607 (+)
• Length: 305 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0A7U4JAV7
• Locus tag: TS85_RS19130
• Protein ID: WP_044334350.1
• Coordinates: 4224088..4224696 (+)
• Length: 203 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TS85_RS19115	4221756..4221953	+	198	WP_155006486.1	hypothetical protein	-
TS85_RS19120	4221969..4222163	+	195	WP_155006487.1	hypothetical protein	-
TS85_RS19125	4222354..4223625	-	1272	WP_162184746.1	MBL fold metallo-hydrolase	-
TS85_RS19130	4224088..4224696	+	609	WP_044334350.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
TS85_RS19135	4224693..4225607	+	915	WP_044334351.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
TS85_RS19140	4225786..4227114	-	1329	WP_044334353.1	amidohydrolase	-
TS85_RS19145	4227224..4230166	-	2943	WP_077228702.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-270)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (9-52)

Sequences

Toxin

Protein

• Length: 305 a.a.
• Molecular weight: 33384.41 Da
• Isoelectric Point: 5.2119

>T52957 WP_044334351.1 NZ_CP010836:4224693-4225607 [Sphingomonas hengshuiensis]
MSRPPKNMAISVRDRLTAVARERRENAQLLMTRYVIERLLFRLSLSPHRDRFVLKGAMLFSLWAAAPYRATGDLDLLGIG
ENAPEQLAAVFQEILGVAVDDDGIVFRPETLRAAAARAEDEYAGVRIDFVAELAGARLPMHVDIGYGDAITPGAIEIEYP
SLLGQPTAHLRAYPPETVVAEKFQAMVALGMLNTRLKDFYDIWAIAGSFAFDGAVLSRAIQATFDRRQTPLPVQTPPALT
PAFADEKQDQWTAFLRRTEIALAPEPFAAIQAQIATLVMPPVLALAQGAGFDSKWPSGGPWQEK

Nucleotide

• Length: 915 bp

>T52957 NZ_CP010836:4224693-4225607 [Sphingomonas hengshuiensis]
ATGAGCCGGCCGCCGAAGAATATGGCGATTTCGGTGCGCGACCGGCTGACGGCGGTTGCCCGCGAGCGCCGGGAAAACGC
ACAGCTGCTAATGACCCGCTACGTCATTGAGCGCCTGCTCTTTCGTCTCAGCCTGTCGCCACATCGCGACCGGTTCGTGC
TCAAGGGCGCGATGCTGTTCAGCCTGTGGGCGGCAGCGCCCTATCGCGCCACCGGCGACCTCGATCTGCTGGGCATAGGG
GAAAATGCGCCCGAGCAGCTCGCAGCGGTTTTTCAGGAAATCCTTGGCGTCGCGGTCGATGACGACGGCATCGTGTTCCG
GCCAGAAACCCTGCGCGCTGCCGCCGCCCGTGCCGAGGATGAATATGCCGGCGTCCGTATCGACTTCGTCGCCGAACTCG
CGGGCGCACGCCTGCCGATGCACGTCGACATCGGCTATGGCGACGCGATCACGCCGGGCGCGATCGAGATCGAATATCCG
TCGTTGCTCGGCCAGCCCACCGCGCATCTTCGGGCCTATCCGCCCGAAACGGTGGTGGCCGAGAAATTCCAGGCCATGGT
CGCGCTCGGTATGCTGAACACGCGCCTGAAGGATTTCTACGATATCTGGGCGATCGCGGGATCGTTCGCGTTCGATGGCG
CCGTGCTGTCGCGCGCCATCCAGGCCACCTTCGATCGCCGCCAAACCCCGTTGCCCGTACAGACGCCTCCGGCGCTCACG
CCCGCCTTCGCCGACGAAAAGCAGGACCAATGGACAGCGTTCCTGCGGCGGACCGAAATCGCGCTGGCGCCCGAACCGTT
CGCGGCAATCCAGGCCCAAATCGCGACGTTGGTAATGCCGCCGGTGCTGGCGCTCGCCCAAGGCGCCGGCTTTGACAGCA
AATGGCCCAGTGGAGGTCCCTGGCAGGAGAAGTGA

Antitoxin

Protein

• Length: 203 a.a.
• Molecular weight: 22379.86 Da
• Isoelectric Point: 9.8244

>AT52957 WP_044334350.1 NZ_CP010836:4224088-4224696 [Sphingomonas hengshuiensis]
MEPTTHRQRALEVVRHRGIARGRDFDAAGITRATLQRLRDEGVLQQVGRGLYKLADAEVDSATSLAEAVRIQPRGVICLL
SALQFHELTTQTPHAVWMMLGQKDWAPVNPSVALKIVRASGEALTAGVETHVIDGVPVPITVPAKTVADCFKHRNKIGID
VAVEALRDFMKSRPRPDLNAIYRYAQLDRVQSVIRPYLEAMT

Nucleotide

• Length: 609 bp

>AT52957 NZ_CP010836:4224088-4224696 [Sphingomonas hengshuiensis]
ATGGAACCGACGACTCATCGACAACGGGCCCTGGAGGTCGTTCGGCACCGCGGCATAGCGCGGGGACGCGATTTCGATGC
GGCCGGCATCACGCGGGCGACCCTGCAAAGGCTGCGTGACGAAGGCGTCCTCCAGCAGGTCGGCCGCGGACTCTACAAGC
TGGCCGATGCTGAGGTCGACAGCGCGACGAGCCTGGCCGAGGCCGTCCGCATCCAGCCACGCGGCGTCATCTGCCTGCTG
TCGGCGCTGCAGTTCCACGAACTGACCACGCAGACGCCCCATGCCGTGTGGATGATGCTCGGCCAAAAGGACTGGGCACC
GGTCAATCCGTCCGTGGCGCTGAAGATTGTTCGCGCGAGCGGCGAAGCGCTGACAGCGGGCGTCGAGACACACGTCATCG
ACGGCGTTCCCGTGCCCATCACCGTACCGGCCAAGACCGTCGCCGACTGCTTCAAGCACCGCAACAAGATCGGTATCGAC
GTGGCGGTCGAGGCCCTGCGCGATTTCATGAAATCCCGACCCCGTCCGGACCTCAATGCGATCTACCGTTACGCCCAGCT
CGATCGGGTCCAATCGGTGATCCGGCCCTACCTAGAAGCCATGACATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4JAV7