Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3530941..3531537 Replicon chromosome
Accession NZ_CP010836
Organism Sphingomonas hengshuiensis strain WHSC-8 isolate soil of Hengshui Lake

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U4LG51
Locus tag TS85_RS15810 Protein ID WP_044333532.1
Coordinates 3531355..3531537 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4LFW6
Locus tag TS85_RS15805 Protein ID WP_044333530.1
Coordinates 3530941..3531333 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TS85_RS15765 3527268..3527771 - 504 WP_044333519.1 P27 family phage terminase small subunit -
TS85_RS15770 3527879..3528202 - 324 WP_077228861.1 HNH endonuclease -
TS85_RS15775 3528210..3528413 - 204 WP_044333521.1 hypothetical protein -
TS85_RS15780 3528423..3528737 - 315 WP_044333523.1 hypothetical protein -
TS85_RS15785 3528737..3529279 - 543 WP_044333524.1 host-nuclease inhibitor Gam family protein -
TS85_RS25485 3529276..3529449 - 174 WP_155006441.1 hypothetical protein -
TS85_RS15790 3529491..3529712 - 222 WP_044333526.1 hypothetical protein -
TS85_RS15795 3529839..3530351 - 513 WP_052508127.1 hypothetical protein -
TS85_RS15800 3530476..3530892 - 417 WP_044333527.1 MarR family transcriptional regulator -
TS85_RS15805 3530941..3531333 - 393 WP_044333530.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TS85_RS15810 3531355..3531537 - 183 WP_044333532.1 type II toxin-antitoxin system HicA family toxin Toxin
TS85_RS15815 3531603..3531974 + 372 WP_044333534.1 thermonuclease family protein -
TS85_RS15820 3531971..3532294 - 324 WP_155006442.1 hypothetical protein -
TS85_RS15825 3532291..3532536 - 246 WP_044333537.1 hypothetical protein -
TS85_RS15830 3532591..3532959 - 369 WP_044333539.1 hypothetical protein -
TS85_RS25490 3532997..3533221 - 225 WP_155006443.1 hypothetical protein -
TS85_RS15835 3533230..3533637 - 408 WP_077228653.1 helix-turn-helix transcriptional regulator -
TS85_RS15840 3533715..3533966 + 252 WP_077228654.1 helix-turn-helix domain-containing protein -
TS85_RS25495 3533963..3534130 + 168 WP_155006444.1 hypothetical protein -
TS85_RS15845 3534495..3534962 + 468 WP_044333543.1 hypothetical protein -
TS85_RS15850 3535269..3535727 + 459 WP_052507961.1 hypothetical protein -
TS85_RS15855 3535724..3535981 + 258 WP_044333545.1 hypothetical protein -
TS85_RS15860 3535981..3536220 + 240 WP_044333547.1 DUF2312 domain-containing protein -
TS85_RS15865 3536217..3536483 + 267 WP_044333549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3501788..3542477 40689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-121)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.01 Da        Isoelectric Point: 11.2826

>T52956 WP_044333532.1 NZ_CP010836:c3531537-3531355 [Sphingomonas hengshuiensis]
MERDSKKIIKRLEAEGWALVSVKGSHHKMAKGTQRVIIPHPKKDLPLGTARSIAKMAGWL

Download         Length: 183 bp

>T52956 NZ_CP010836:c3531537-3531355 [Sphingomonas hengshuiensis]
ATGGAACGGGATAGCAAAAAGATCATCAAGCGCCTCGAAGCCGAGGGATGGGCGCTGGTTTCGGTCAAGGGCTCGCACCA
CAAGATGGCGAAGGGCACGCAGCGTGTGATCATCCCGCACCCGAAGAAAGACCTGCCGCTCGGCACGGCGCGGTCGATAG
CGAAAATGGCGGGCTGGCTCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14009.92 Da        Isoelectric Point: 4.4101

>AT52956 WP_044333530.1 NZ_CP010836:c3531333-3530941 [Sphingomonas hengshuiensis]
MKTYFAIVHKDPDSAYGVTFPDLPGCFSAADRLADVVPNACEAMDLWFDADAVIEPREAEEIAAEYAEDLAKGAFLIAVP
RVARTGAPVRINISLDRGILNAIDAAASARKLTRSAFIAEATKNEIEMAH

Download         Length: 393 bp

>AT52956 NZ_CP010836:c3531333-3530941 [Sphingomonas hengshuiensis]
ATGAAGACGTATTTTGCGATCGTGCACAAGGATCCGGATAGCGCCTATGGCGTGACCTTCCCGGATCTGCCCGGGTGCTT
CTCGGCTGCCGACAGGTTGGCCGACGTCGTTCCCAATGCGTGCGAGGCGATGGATCTGTGGTTCGATGCCGACGCGGTGA
TCGAACCGCGCGAGGCGGAAGAGATTGCCGCCGAATATGCGGAGGATCTGGCGAAGGGCGCTTTCCTCATCGCGGTTCCC
CGCGTGGCCCGGACGGGGGCGCCGGTGCGCATCAACATTTCGCTCGATCGCGGCATCCTCAACGCGATCGACGCGGCGGC
GAGCGCGCGCAAGCTGACCCGCAGCGCGTTCATCGCGGAGGCGACCAAGAACGAGATCGAGATGGCGCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4LG51

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4LFW6

References