Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 2219173..2219701 Replicon chromosome
Accession NZ_CP010836
Organism Sphingomonas hengshuiensis strain WHSC-8 isolate soil of Hengshui Lake

Toxin (Protein)


Gene name parE Uniprot ID A0A7U4LFC8
Locus tag TS85_RS09810 Protein ID WP_044331903.1
Coordinates 2219411..2219701 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U5HVR8
Locus tag TS85_RS09805 Protein ID WP_044336122.1
Coordinates 2219173..2219418 (+) Length 82 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TS85_RS09785 2215113..2215466 + 354 WP_044331899.1 hypothetical protein -
TS85_RS24610 2215630..2216631 + 1002 WP_077228505.1 IS30 family transposase -
TS85_RS09795 2216784..2218187 + 1404 WP_044331901.1 serine hydrolase -
TS85_RS09800 2218184..2219098 + 915 WP_044331902.1 hypothetical protein -
TS85_RS09805 2219173..2219418 + 246 WP_044336122.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
TS85_RS09810 2219411..2219701 + 291 WP_044331903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TS85_RS09815 2219720..2222104 - 2385 WP_044336123.1 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family -
TS85_RS09820 2222485..2223879 + 1395 WP_044331904.1 leucyl aminopeptidase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin

(7-80)


Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11257.92 Da        Isoelectric Point: 9.0791

>T52955 WP_044331903.1 NZ_CP010836:2219411-2219701 [Sphingomonas hengshuiensis]
MAEYRLSPKAQRDLESVFDYTRAQWGLPQAMRYIDLIEAACADLAEAPHRAQDCTHIRPGYRRRTVEQHVLYFRLASHGI
AIIRILHQRMDTARHL

Download         Length: 291 bp

>T52955 NZ_CP010836:2219411-2219701 [Sphingomonas hengshuiensis]
ATGGCTGAATATCGGCTCAGTCCGAAGGCACAGCGCGATCTCGAATCGGTATTCGATTATACCAGGGCGCAATGGGGATT
GCCCCAGGCCATGCGCTACATCGATCTGATTGAAGCCGCCTGCGCCGATCTTGCCGAAGCGCCGCATCGCGCGCAGGACT
GCACGCACATCCGCCCTGGCTATCGCCGGCGGACTGTAGAGCAGCACGTCCTCTATTTTCGGCTGGCGAGCCATGGCATC
GCCATCATTCGAATCCTCCATCAGCGCATGGATACGGCCCGTCACCTGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9278.26 Da        Isoelectric Point: 5.7135

>AT52955 WP_044336122.1 NZ_CP010836:2219173-2219418 [Sphingomonas hengshuiensis]
MATVRKTITLTEQQDAWIAAQIDAGHYTNDSEAIRDLIRREQERSFEIESLRHALIAGEQSGEPERFDFAAFKRRKSAQN
G

Download         Length: 246 bp

>AT52955 NZ_CP010836:2219173-2219418 [Sphingomonas hengshuiensis]
ATGGCGACGGTACGCAAGACGATCACGCTGACCGAGCAGCAGGATGCGTGGATCGCCGCGCAGATCGACGCCGGCCACTA
TACCAACGACAGCGAGGCGATCCGCGACCTTATCCGGCGCGAGCAGGAGCGGAGTTTCGAGATTGAGAGCCTGCGCCATG
CGTTGATCGCGGGCGAGCAGAGCGGCGAGCCCGAGCGCTTCGACTTCGCGGCGTTCAAGCGGCGAAAATCCGCGCAAAAT
GGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4LFC8


Antitoxin

Source ID Structure
AlphaFold DB A0A7U5HVR8

References