Detailed information of TA system TA052954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 655171..655619
• Replicon: chromosome
• Accession: NZ_CP010836
• Organism: Sphingomonas hengshuiensis strain WHSC-8 isolate soil of Hengshui Lake

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TS85_RS03135
• Protein ID: WP_173426212.1
• Coordinates: 655171..655443 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7U4LE68
• Locus tag: TS85_RS03140
• Protein ID: WP_044330358.1
• Coordinates: 655443..655619 (-)
• Length: 59 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TS85_RS03095	650886..651287	+	402	WP_044330352.1	low affinity iron permease family protein	-
TS85_RS03100	651306..651734	-	429	WP_044330353.1	OsmC family protein	-
TS85_RS03105	651847..652260	-	414	WP_077228790.1	glycine zipper 2TM domain-containing protein	-
TS85_RS03110	652321..652641	-	321	WP_044330354.1	hypothetical protein	-
TS85_RS03115	652877..653095	-	219	WP_044330355.1	hypothetical protein	-
TS85_RS03120	653174..653383	-	210	WP_044330356.1	cold-shock protein	-
TS85_RS03125	653563..653958	-	396	WP_044330357.1	cupin domain-containing protein	-
TS85_RS23920	653968..655047	-	1080	WP_052507699.1	hypothetical protein	-
TS85_RS03135	655171..655443	-	273	WP_173426212.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TS85_RS03140	655443..655619	-	177	WP_044330358.1	hypothetical protein	Antitoxin
TS85_RS03145	655679..655897	-	219	WP_044330359.1	DUF433 domain-containing protein	-
TS85_RS25175	656063..657589	+	1527	WP_155006279.1	hypothetical protein	-
TS85_RS03150	657793..658164	-	372	WP_044330362.1	hypothetical protein	-
TS85_RS25180	658158..658310	-	153	WP_162184668.1	hypothetical protein	-
TS85_RS03155	658324..658899	-	576	WP_044330363.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10439.02 Da
• Isoelectric Point: 6.7581

>T52954 WP_173426212.1 NZ_CP010836:c655443-655171 [Sphingomonas hengshuiensis]
MLPLLWHPEALEDLEHIVDFIEARNPRAAQRLSALIRDTADRLPDHPYVHRPGRVPGTREAVVHPNYILIYRVADYIEVM
GVLHARQPYP

Nucleotide

• Length: 273 bp

>T52954 NZ_CP010836:c655443-655171 [Sphingomonas hengshuiensis]
ATGCTGCCGCTGCTCTGGCACCCGGAGGCGCTGGAGGATCTCGAACACATCGTCGACTTCATCGAAGCGCGTAATCCGCG
CGCCGCGCAGCGTCTCAGCGCGTTGATCCGCGACACCGCCGATCGCCTGCCCGATCACCCCTATGTCCATCGCCCCGGTC
GCGTGCCCGGCACGCGGGAAGCGGTCGTCCACCCCAATTACATCCTGATTTACCGCGTCGCGGACTATATCGAGGTGATG
GGCGTCCTCCACGCCCGCCAACCCTACCCCTGA

Antitoxin

Protein

• Length: 59 a.a.
• Molecular weight: 6434.33 Da
• Isoelectric Point: 5.7834

>AT52954 WP_044330358.1 NZ_CP010836:c655619-655443 [Sphingomonas hengshuiensis]
MAKLSPIESEFESTEAADAYDAWFRAKIEARMASKAPGIPHDEAMARVQVILDRRKAG

Nucleotide

• Length: 177 bp

>AT52954 NZ_CP010836:c655619-655443 [Sphingomonas hengshuiensis]
ATGGCCAAGCTCTCGCCCATCGAGTCCGAATTCGAATCGACCGAAGCCGCCGACGCCTATGACGCATGGTTTCGCGCGAA
GATCGAAGCGCGCATGGCTTCCAAGGCTCCCGGCATCCCGCACGACGAAGCGATGGCGCGGGTACAGGTGATCCTGGATC
GTCGCAAAGCCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4LE68