Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3212432..3213086 Replicon chromosome
Accession NZ_CP010829
Organism Shigella sonnei strain FORC_011

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag FORC11_RS16840 Protein ID WP_000244777.1
Coordinates 3212432..3212839 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FORC11_RS16845 Protein ID WP_000354046.1
Coordinates 3212820..3213086 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC11_RS16820 (3208389) 3208389..3210122 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
FORC11_RS16825 (3210128) 3210128..3210838 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FORC11_RS16830 (3210863) 3210863..3211759 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FORC11_RS16835 (3211871) 3211871..3212392 + 522 WP_001055874.1 flavodoxin FldB -
FORC11_RS16840 (3212432) 3212432..3212839 - 408 WP_000244777.1 protein YgfX Toxin
FORC11_RS16845 (3212820) 3212820..3213086 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FORC11_RS16850 (3213329) 3213329..3214309 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
FORC11_RS16855 (3214505) 3214505..3215164 - 660 WP_000250274.1 hemolysin III family protein -
FORC11_RS16860 (3215328) 3215328..3215639 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
FORC11_RS16865 (3215684) 3215684..3217117 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
FORC11_RS16870 (3217174) 3217174..3217917 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T52943 WP_000244777.1 NZ_CP010829:c3212839-3212432 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T52943 NZ_CP010829:c3212839-3212432 [Shigella sonnei]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT52943 WP_000354046.1 NZ_CP010829:c3213086-3212820 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT52943 NZ_CP010829:c3213086-3212820 [Shigella sonnei]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References