Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1660099..1660583 Replicon chromosome
Accession NZ_CP010829
Organism Shigella sonnei strain FORC_011

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag FORC11_RS08655 Protein ID WP_014334020.1
Coordinates 1660099..1660389 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag FORC11_RS08660 Protein ID WP_005142544.1
Coordinates 1660389..1660583 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC11_RS08620 (1655170) 1655170..1655784 - 615 WP_000148710.1 Tat proofreading chaperone DmsD -
FORC11_RS08625 (1655827) 1655827..1656681 - 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
FORC11_RS08630 (1656683) 1656683..1657300 - 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
FORC11_RS08635 (1657311) 1657311..1658387 - 1077 Protein_1632 molybdopterin dinucleotide binding domain-containing protein -
FORC11_RS08640 (1658445) 1658445..1659142 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
FORC11_RS08645 (1659290) 1659290..1659655 - 366 WP_024174355.1 hypothetical protein -
FORC11_RS08650 (1659667) 1659667..1659819 - 153 WP_000379558.1 DUF1391 family protein -
FORC11_RS08655 (1660099) 1660099..1660389 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC11_RS08660 (1660389) 1660389..1660583 - 195 WP_005142544.1 hypothetical protein Antitoxin
FORC11_RS08665 (1660603) 1660603..1661088 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
FORC11_RS28110 (1661215) 1661215..1661478 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
FORC11_RS08670 (1661475) 1661475..1661900 + 426 WP_000693826.1 toxin YdaT family protein -
FORC11_RS08675 (1661972) 1661972..1663036 + 1065 WP_001262380.1 hypothetical protein -
FORC11_RS08680 (1663043) 1663043..1663789 + 747 WP_000788740.1 ATP-binding protein -
FORC11_RS08685 (1663811) 1663811..1664536 + 726 WP_000450631.1 DUF1627 domain-containing protein -
FORC11_RS08690 (1664552) 1664552..1664974 + 423 WP_001151171.1 DUF977 family protein -
FORC11_RS08695 (1665032) 1665032..1665388 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / rhs/PAAR / rhs/PAAR / vgrG/tssI 1569461..1795670 226209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T52939 WP_014334020.1 NZ_CP010829:c1660389-1660099 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T52939 NZ_CP010829:c1660389-1660099 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT52939 WP_005142544.1 NZ_CP010829:c1660583-1660389 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT52939 NZ_CP010829:c1660583-1660389 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References