Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 474369..474987 Replicon chromosome
Accession NZ_CP010829
Organism Shigella sonnei strain FORC_011

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FORC11_RS02400 Protein ID WP_001291435.1
Coordinates 474369..474587 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag FORC11_RS02405 Protein ID WP_000344804.1
Coordinates 474613..474987 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC11_RS02365 (469661) 469661..470233 + 573 WP_000779812.1 YbaY family lipoprotein -
FORC11_RS02370 (470264) 470264..470575 - 312 WP_000409911.1 MGMT family protein -
FORC11_RS02380 (470954) 470954..471307 + 354 WP_000878140.1 DUF1428 domain-containing protein -
FORC11_RS02385 (471349) 471349..472897 - 1549 Protein_446 cyclic-guanylate-specific phosphodiesterase PdeB -
FORC11_RS02390 (473061) 473061..473531 - 471 WP_000136192.1 YlaC family protein -
FORC11_RS02395 (473647) 473647..474198 - 552 WP_000102564.1 maltose O-acetyltransferase -
FORC11_RS02400 (474369) 474369..474587 - 219 WP_001291435.1 HHA domain-containing protein Toxin
FORC11_RS02405 (474613) 474613..474987 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
FORC11_RS02410 (475533) 475533..478682 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
FORC11_RS02415 (478705) 478705..479898 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T52930 WP_001291435.1 NZ_CP010829:c474587-474369 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T52930 NZ_CP010829:c474587-474369 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT52930 WP_000344804.1 NZ_CP010829:c474987-474613 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT52930 NZ_CP010829:c474987-474613 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGAGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References