Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 371707..372224 Replicon chromosome
Accession NZ_CP010827
Organism Corynebacterium singulare strain IBS B52218

Toxin (Protein)


Gene name relB Uniprot ID A0A0B6EY74
Locus tag CSING_RS01670 Protein ID WP_042529146.1
Coordinates 371707..371961 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B6F0B7
Locus tag CSING_RS01675 Protein ID WP_042529149.1
Coordinates 371958..372224 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSING_RS01645 367075..368052 + 978 WP_042529137.1 porphobilinogen synthase -
CSING_RS01650 368076..368765 + 690 WP_042529139.1 hypothetical protein -
CSING_RS01655 368762..369259 + 498 WP_042529141.1 hypothetical protein -
CSING_RS01660 369298..370338 + 1041 WP_042529143.1 uroporphyrinogen decarboxylase -
CSING_RS01665 370339..371706 + 1368 WP_042529145.1 protoporphyrinogen oxidase -
CSING_RS01670 371707..371961 - 255 WP_042529146.1 Txe/YoeB family addiction module toxin Toxin
CSING_RS01675 371958..372224 - 267 WP_042529149.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CSING_RS01680 372288..373805 - 1518 WP_042529151.1 ATP-binding cassette domain-containing protein -
CSING_RS01685 373889..374905 - 1017 WP_042529153.1 hypothetical protein -
CSING_RS01690 374905..375483 - 579 WP_042529155.1 ATP-binding cassette domain-containing protein -
CSING_RS13515 375655..375846 + 192 WP_144403095.1 hypothetical protein -
CSING_RS01695 375863..376486 + 624 WP_042533025.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10086.54 Da        Isoelectric Point: 8.9068

>T52925 WP_042529146.1 NZ_CP010827:c371961-371707 [Corynebacterium singulare]
MILSWAEEAWEDYLWWQSHDKKNLKRINNLIKDIPRNGNEGIGKPEPLKFELAGFWSRRITEEHRLVYRIKGGTIEIAGC
RYHY

Download         Length: 255 bp

>T52925 NZ_CP010827:c371961-371707 [Corynebacterium singulare]
ATGATTCTTTCGTGGGCAGAGGAAGCATGGGAGGACTACCTCTGGTGGCAGTCTCACGACAAGAAGAACCTCAAGAGAAT
CAATAACCTCATTAAGGACATTCCACGAAACGGCAACGAAGGGATAGGCAAGCCCGAACCTCTCAAATTCGAGTTGGCCG
GATTTTGGTCTCGGCGAATTACTGAAGAACACCGACTGGTCTATCGCATTAAGGGTGGAACCATCGAGATTGCTGGGTGC
AGATACCACTACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10110.24 Da        Isoelectric Point: 4.7119

>AT52925 WP_042529149.1 NZ_CP010827:c372224-371958 [Corynebacterium singulare]
MKTMSYSESRARYAEVLQSVVDDREEVIITRNGHESAVIVSLDDYNSLRETAYLLRSPRNAQRLLDSIEKLDAGEAAQHE
LIEETKRQ

Download         Length: 267 bp

>AT52925 NZ_CP010827:c372224-371958 [Corynebacterium singulare]
ATGAAGACCATGTCTTACTCGGAATCAAGAGCACGGTACGCCGAAGTATTGCAGTCGGTTGTTGATGACCGCGAGGAAGT
CATCATCACTCGCAATGGCCATGAGTCTGCAGTCATCGTTTCCTTAGATGACTACAACTCTCTTCGCGAAACTGCTTACC
TTTTGCGCTCCCCTCGCAATGCGCAGCGCTTGCTCGATTCCATTGAGAAACTTGACGCTGGAGAAGCAGCGCAACACGAA
CTCATCGAGGAAACTAAACGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B6EY74

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6F0B7

References