Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/Phd-LOTUS_5_Limkain_b1
Location 13393..14080 Replicon plasmid pTA78
Accession NZ_CP010826
Organism Thermus aquaticus Y51MC23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TO73_RS12220 Protein ID WP_003048852.1
Coordinates 13393..13656 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TO73_RS12225 Protein ID WP_003048855.1
Coordinates 13664..14080 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TO73_RS12195 9055..10224 - 1170 Protein_8 IS256 family transposase -
TO73_RS13130 10826..11410 + 585 WP_155982929.1 hypothetical protein -
TO73_RS12200 11440..11700 - 261 WP_003048844.1 hypothetical protein -
TO73_RS12205 12035..12304 + 270 WP_003048845.1 hypothetical protein -
TO73_RS12210 12279..12521 + 243 Protein_12 hypothetical protein -
TO73_RS13135 12519..13211 + 693 Protein_13 peptidase S8 and S53 subtilisin kexin sedolisin -
TO73_RS12220 13393..13656 + 264 WP_003048852.1 type II toxin-antitoxin system Phd/YefM family antitoxin Toxin
TO73_RS12225 13664..14080 + 417 WP_003048855.1 type II toxin-antitoxin system VapC family toxin Antitoxin
TO73_RS12820 14324..14473 - 150 WP_081453679.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..78727 78727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-66)

Antitoxin

PIN domain

(3-122)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9990.47 Da        Isoelectric Point: 8.6587

>T52923 WP_003048852.1 NZ_CP010826:13393-13656 [Thermus aquaticus Y51MC23]
MARTWQLQEAKARFSKLVEEALKGEPQLVTRRGRKAVVVLDWETYARLTGEKLALWQALRAPTPLPNDEAEALFARTEAE
HREVSLF

Download         Length: 264 bp

>T52923 NZ_CP010826:13393-13656 [Thermus aquaticus Y51MC23]
ATGGCCAGGACCTGGCAACTGCAAGAGGCCAAGGCCCGCTTCTCCAAGCTGGTGGAGGAGGCGCTAAAGGGCGAGCCCCA
GCTGGTCACCCGGCGGGGCCGCAAGGCGGTGGTGGTCCTGGACTGGGAAACCTACGCCCGGCTCACGGGGGAGAAGCTCG
CCCTCTGGCAAGCCCTCCGCGCCCCCACACCCCTCCCCAACGATGAGGCGGAGGCCCTCTTCGCCCGGACGGAGGCGGAG
CACCGGGAGGTCTCCCTCTTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15211.76 Da        Isoelectric Point: 9.8249

>AT52923 WP_003048855.1 NZ_CP010826:13664-14080 [Thermus aquaticus Y51MC23]
VAYLLDTNVLSETVKARPDPQVVAWLEETPLGEAYLSALTWGELVQGVVRAPVGRRRALESWLRGVRRSFQGRILPLDLP
VMEVWGRLVGEAFLKGKPLSPLDAMLAATALHHGLVLATRNVRHFEGLPIALFNPWGG

Download         Length: 417 bp

>AT52923 NZ_CP010826:13664-14080 [Thermus aquaticus Y51MC23]
GTGGCCTACCTCTTGGACACCAACGTCCTCTCCGAGACGGTCAAGGCCCGGCCGGACCCCCAGGTGGTGGCCTGGTTGGA
GGAGACGCCCCTGGGAGAGGCTTACCTTTCGGCCCTGACGTGGGGGGAGCTGGTCCAGGGTGTGGTCCGGGCCCCGGTGG
GGCGAAGGCGGGCCTTGGAGTCCTGGCTTCGGGGGGTGAGGCGGTCTTTCCAAGGGCGAATCCTGCCCCTGGACCTCCCG
GTGATGGAAGTCTGGGGCCGCCTGGTGGGCGAGGCCTTTTTGAAGGGCAAACCCCTCTCCCCCCTGGACGCCATGCTGGC
CGCCACGGCGCTGCACCACGGTTTGGTCCTGGCGACCCGGAACGTGCGCCACTTTGAGGGCCTGCCCATCGCCCTCTTCA
ACCCCTGGGGCGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References