Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1671866..1672518 Replicon chromosome
Accession NZ_CP010822
Organism Thermus aquaticus Y51MC23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TO73_RS08850 Protein ID WP_003045164.1
Coordinates 1672126..1672518 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TO73_RS08845 Protein ID WP_003045162.1
Coordinates 1671866..1672126 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TO73_RS08825 1667895..1668950 + 1056 WP_003045156.1 FAD-binding protein -
TO73_RS08830 1668955..1670211 + 1257 WP_003045158.1 glycolate oxidase subunit GlcF -
TO73_RS13035 1670358..1670552 + 195 WP_050764265.1 hypothetical protein -
TO73_RS08840 1670549..1671778 + 1230 WP_050764266.1 CAP domain-containing protein -
TO73_RS08845 1671866..1672126 + 261 WP_003045162.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TO73_RS08850 1672126..1672518 + 393 WP_003045164.1 type II toxin-antitoxin system VapC family toxin Toxin
TO73_RS08855 1672503..1673723 + 1221 WP_003045166.1 DUF4147 domain-containing protein -
TO73_RS08860 1673747..1674853 + 1107 WP_003045168.1 radical SAM family heme chaperone HemW -
TO73_RS08865 1674917..1675306 - 390 WP_003045171.1 NADH-quinone oxidoreductase subunit 15 -
TO73_RS08880 1675596..1677023 + 1428 WP_040684201.1 2-phosphoglycerate kinase -
TO73_RS08885 1677016..1677354 + 339 WP_003045174.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14487.61 Da        Isoelectric Point: 5.2629

>T52922 WP_003045164.1 NZ_CP010822:1672126-1672518 [Thermus aquaticus Y51MC23]
MVLDTSALLAILFREEGYEDLLEEIRRAHPRKVAAPTLAEAGIVLGARLGFERVYLLLALLSELQAEVIPFSEAHAREAI
SAYRRYGRGRHPAGLNFGDCLSYALAKVEGEPLLYKGEDFDRTDLAWKPS

Download         Length: 393 bp

>T52922 NZ_CP010822:1672126-1672518 [Thermus aquaticus Y51MC23]
ATGGTACTGGACACTTCCGCCCTCCTGGCCATCCTCTTTCGGGAAGAGGGGTACGAGGACCTGCTGGAAGAGATCCGGCG
CGCCCATCCCCGCAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTTCTAGGCGCCCGGCTGGGTTTTGAACGGG
TATACCTTCTTCTCGCCCTCCTAAGCGAACTCCAGGCCGAGGTCATCCCCTTCAGCGAAGCGCACGCCCGGGAAGCCATT
TCCGCTTACCGCCGCTATGGGCGGGGGAGGCACCCCGCCGGCCTCAACTTCGGGGACTGCCTGAGCTACGCCCTGGCCAA
GGTAGAGGGGGAGCCCCTCCTCTACAAGGGCGAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9883.49 Da        Isoelectric Point: 6.4290

>AT52922 WP_003045162.1 NZ_CP010822:1671866-1672126 [Thermus aquaticus Y51MC23]
MALTVRNKEVERLAEEVARLAGETKTEAIRKALEMRLKLLKGKRGFDRVLRFLEEEVWPQIPPELLGKGISKEEEEAILG
YGREGY

Download         Length: 261 bp

>AT52922 NZ_CP010822:1671866-1672126 [Thermus aquaticus Y51MC23]
ATGGCCCTTACCGTCCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTGGCGGGGGAGACCAAGACCGA
GGCCATCCGCAAGGCCCTGGAGATGCGCCTCAAGCTGCTGAAGGGCAAGCGGGGCTTTGACCGGGTGCTCCGCTTCCTGG
AAGAGGAGGTCTGGCCCCAGATACCCCCGGAGCTTTTGGGAAAGGGCATCTCCAAGGAAGAAGAGGAAGCCATCCTCGGC
TACGGCAGGGAGGGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References