52921

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4410907..4411721 Replicon chromosome
Accession NZ_CP010816
Organism Escherichia coli strain BL21 (TaKaRa)

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag SR36_RS21790 Protein ID WP_001054376.1
Coordinates 4411464..4411721 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag SR36_RS21785 Protein ID WP_001309181.1
Coordinates 4410907..4411452 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SR36_RS21765 (SR36_21765) 4406598..4407911 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
SR36_RS21770 (SR36_21770) 4407923..4408201 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
SR36_RS21775 (SR36_21775) 4408198..4409319 - 1122 WP_000010829.1 M42 family metallopeptidase -
SR36_RS25390 4409564..4409680 - 117 Protein_4129 VOC family protein -
SR36_RS24825 4409718..4409936 - 219 Protein_4130 hypothetical protein -
SR36_RS21780 (SR36_21780) 4410105..4410851 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
SR36_RS21785 (SR36_21785) 4410907..4411452 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
SR36_RS21790 (SR36_21790) 4411464..4411721 - 258 WP_001054376.1 hypothetical protein Toxin
SR36_RS25230 4412098..4412343 - 246 Protein_4134 GNAT family N-acetyltransferase -
SR36_RS21805 (SR36_21805) 4412459..4413699 + 1241 Protein_4135 helicase YjhR -
SR36_RS21810 (SR36_21810) 4414282..4415262 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
SR36_RS21815 (SR36_21815) 4415327..4416433 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T52921 WP_001054376.1 NZ_CP010816:c4411721-4411464 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T52921 NZ_CP010816:c4411721-4411464 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT52921 WP_001309181.1 NZ_CP010816:c4411452-4410907 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT52921 NZ_CP010816:c4411452-4410907 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References