Detailed information of TA system TA052893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/GNAT(toxin)
• Location: 812396..813024
• Replicon: chromosome
• Accession: NZ_CP010812
• Organism: Vibrio cholerae strain 10432-62

Toxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: VAB027_RS03900
• Protein ID: WP_046126179.1
• Coordinates: 812548..813024 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: VAB027_RS19400
• Protein ID: WP_080341696.1
• Coordinates: 812396..812491 (-)
• Length: 32 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAB027_RS03865	807507..808241	-	735	WP_046126214.1	hypothetical protein	-
VAB027_RS03870	808235..809557	-	1323	WP_046126215.1	AAA family ATPase	-
VAB027_RS03875	809737..810273	-	537	WP_042989109.1	GNAT family N-acetyltransferase	-
VAB027_RS03880	810431..810718	-	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VAB027_RS03885	810708..810959	-	252	WP_001250177.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VAB027_RS03890	811185..811784	-	600	WP_046126216.1	porin family protein	-
VAB027_RS03895	811951..812364	-	414	WP_046126217.1	VOC family protein	-
VAB027_RS19400	812396..812491	-	96	WP_080341696.1	acetyltransferase	Antitoxin
VAB027_RS03900	812548..813024	-	477	WP_046126179.1	GNAT family N-acetyltransferase	Toxin
VAB027_RS03905	813294..813572	-	279	WP_032469024.1	DUF3709 domain-containing protein	-
VAB027_RS03910	813798..814550	-	753	WP_046126218.1	hypothetical protein	-
VAB027_RS03915	814713..815246	-	534	WP_032479087.1	adenylate kinase	-
VAB027_RS03920	815455..815636	-	182	Protein_769	DUF645 family protein	-
VAB027_RS03925	815933..816433	-	501	WP_046126219.1	NAD(P)H-dependent oxidoreductase	-
VAB027_RS19405	816631..816812	-	182	Protein_771	DUF645 family protein	-
VAB027_RS03940	817107..817562	-	456	WP_046126220.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	737949..818855	80906
	-	inside	Integron	-	-	741722..820081	78359

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (36-139)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 18382.18 Da
• Isoelectric Point: 6.7088

>T52893 WP_046126179.1 NZ_CP010812:c813024-812548 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGGPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNSYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVSTEIGTRAFNGKLWDLVRMEKRL

Nucleotide

• Length: 477 bp

>T52893 NZ_CP010812:c813024-812548 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTGGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATTCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTTCGACAGAAATTGGTACAAGAGCTTTTAATGGTAAGTTATGGGATCTGGTGCGAATGGAAAAACGGTTATAA

Antitoxin

Protein

• Length: 32 a.a.
• Molecular weight: 3465.26 Da
• Isoelectric Point: 8.5638

>AT52893 WP_080341696.1 NZ_CP010812:c812491-812396 [Vibrio cholerae]
VVMVVVIEFGGMRCQPLRRALCAFSKNLEVV

Nucleotide

• Length: 96 bp

>AT52893 NZ_CP010812:c812491-812396 [Vibrio cholerae]
GTGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTGCTTTCTCGAAAAA
TCTCGAAGTAGTGTAG