52890

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 806184..806682 Replicon chromosome
Accession NZ_CP010812
Organism Vibrio cholerae strain 10432-62

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag VAB027_RS03860 Protein ID WP_000589156.1
Coordinates 806416..806682 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag VAB027_RS03855 Protein ID WP_000643598.1
Coordinates 806184..806429 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VAB027_RS03815 801510..801692 - 183 WP_046126209.1 DUF645 family protein -
VAB027_RS20340 802118..802192 - 75 WP_108244119.1 hypothetical protein -
VAB027_RS20345 802205..802357 - 153 WP_142741475.1 DUF3709 domain-containing protein -
VAB027_RS19360 802347..802514 - 168 WP_080341693.1 DUF3265 domain-containing protein -
VAB027_RS20170 802454..802756 - 303 WP_046126210.1 hypothetical protein -
VAB027_RS03825 802907..803242 - 336 WP_039445746.1 hypothetical protein -
VAB027_RS19365 803269..803385 - 117 WP_079878422.1 DUF3265 domain-containing protein -
VAB027_RS19910 803376..804053 - 678 WP_046126211.1 hypothetical protein -
VAB027_RS03835 804218..804757 - 540 WP_046126212.1 hydrolase -
VAB027_RS03840 804911..805198 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
VAB027_RS03845 805188..805439 - 252 WP_046126213.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VAB027_RS03850 805703..805885 - 183 WP_009355233.1 DUF645 family protein -
VAB027_RS03855 806184..806429 - 246 WP_000643598.1 hypothetical protein Antitoxin
VAB027_RS03860 806416..806682 - 267 WP_000589156.1 BrnT family toxin Toxin
VAB027_RS20350 806703..806801 - 99 WP_200894328.1 acetyltransferase -
VAB027_RS19380 806990..807226 - 237 WP_080341695.1 DUF3709 domain-containing protein -
VAB027_RS19385 807386..807478 - 93 Protein_756 DUF3265 domain-containing protein -
VAB027_RS03865 807507..808241 - 735 WP_046126214.1 hypothetical protein -
VAB027_RS03870 808235..809557 - 1323 WP_046126215.1 AAA family ATPase -
VAB027_RS03875 809737..810273 - 537 WP_042989109.1 GNAT family N-acetyltransferase -
VAB027_RS03880 810431..810718 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
VAB027_RS03885 810708..810959 - 252 WP_001250177.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 737949..818855 80906
- inside Integron - - 741722..820081 78359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T52890 WP_000589156.1 NZ_CP010812:c806682-806416 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T52890 NZ_CP010812:c806682-806416 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT52890 WP_000643598.1 NZ_CP010812:c806429-806184 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT52890 NZ_CP010812:c806429-806184 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References