Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 804911..805439 | Replicon | chromosome |
| Accession | NZ_CP010812 | ||
| Organism | Vibrio cholerae strain 10432-62 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0X1KZS6 |
| Locus tag | VAB027_RS03840 | Protein ID | WP_000221354.1 |
| Coordinates | 804911..805198 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | VAB027_RS03845 | Protein ID | WP_046126213.1 |
| Coordinates | 805188..805439 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAB027_RS19350 | 800197..800433 | - | 237 | WP_080341691.1 | DUF3709 domain-containing protein | - |
| VAB027_RS03805 | 800715..801050 | - | 336 | WP_046126207.1 | hypothetical protein | - |
| VAB027_RS03815 | 801510..801692 | - | 183 | WP_046126209.1 | DUF645 family protein | - |
| VAB027_RS20340 | 802118..802192 | - | 75 | WP_108244119.1 | hypothetical protein | - |
| VAB027_RS20345 | 802205..802357 | - | 153 | WP_142741475.1 | DUF3709 domain-containing protein | - |
| VAB027_RS19360 | 802347..802514 | - | 168 | WP_080341693.1 | DUF3265 domain-containing protein | - |
| VAB027_RS20170 | 802454..802756 | - | 303 | WP_046126210.1 | hypothetical protein | - |
| VAB027_RS03825 | 802907..803242 | - | 336 | WP_039445746.1 | hypothetical protein | - |
| VAB027_RS19365 | 803269..803385 | - | 117 | WP_079878422.1 | DUF3265 domain-containing protein | - |
| VAB027_RS19910 | 803376..804053 | - | 678 | WP_046126211.1 | hypothetical protein | - |
| VAB027_RS03835 | 804218..804757 | - | 540 | WP_046126212.1 | hydrolase | - |
| VAB027_RS03840 | 804911..805198 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VAB027_RS03845 | 805188..805439 | - | 252 | WP_046126213.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VAB027_RS03850 | 805703..805885 | - | 183 | WP_009355233.1 | DUF645 family protein | - |
| VAB027_RS03855 | 806184..806429 | - | 246 | WP_000643598.1 | hypothetical protein | - |
| VAB027_RS03860 | 806416..806682 | - | 267 | WP_000589156.1 | BrnT family toxin | - |
| VAB027_RS20350 | 806703..806801 | - | 99 | WP_200894328.1 | acetyltransferase | - |
| VAB027_RS19380 | 806990..807226 | - | 237 | WP_080341695.1 | DUF3709 domain-containing protein | - |
| VAB027_RS19385 | 807386..807478 | - | 93 | Protein_756 | DUF3265 domain-containing protein | - |
| VAB027_RS03865 | 807507..808241 | - | 735 | WP_046126214.1 | hypothetical protein | - |
| VAB027_RS03870 | 808235..809557 | - | 1323 | WP_046126215.1 | AAA family ATPase | - |
| VAB027_RS03875 | 809737..810273 | - | 537 | WP_042989109.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 737949..818855 | 80906 | |
| - | inside | Integron | - | - | 741722..820081 | 78359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T52889 WP_000221354.1 NZ_CP010812:c805198-804911 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T52889 NZ_CP010812:c805198-804911 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCATGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGACGAGATAGTTGTCTATGTCCTTGCTGTCGGCAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTTGGTTAG
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCATGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGACGAGATAGTTGTCTATGTCCTTGCTGTCGGCAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTTGGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9180.34 Da Isoelectric Point: 4.0197
>AT52889 WP_046126213.1 NZ_CP010812:c805439-805188 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRVDLSQAVEVNI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRVDLSQAVEVNI
DDL
Download Length: 252 bp
>AT52889 NZ_CP010812:c805439-805188 [Vibrio cholerae]
ATGAGACAGGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGTGGACTTATCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
ATGAGACAGGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGTGGACTTATCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|