Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 795708..796236 Replicon chromosome
Accession NZ_CP010812
Organism Vibrio cholerae strain 10432-62

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag VAB027_RS03770 Protein ID WP_000221352.1
Coordinates 795946..796236 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag VAB027_RS03765 Protein ID WP_000213183.1
Coordinates 795708..795956 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VAB027_RS03730 790900..791421 - 522 WP_000921691.1 DUF2442 domain-containing protein -
VAB027_RS03735 791415..791684 - 270 WP_001114075.1 DUF4160 domain-containing protein -
VAB027_RS20240 791936..792031 - 96 WP_001907607.1 DUF645 family protein -
VAB027_RS03740 792442..792720 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VAB027_RS03745 792713..792982 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
VAB027_RS20150 793578..794003 - 426 WP_052724878.1 hypothetical protein -
VAB027_RS03755 794150..794848 - 699 WP_046126203.1 HAD family phosphatase -
VAB027_RS03760 794939..795496 - 558 WP_046126204.1 GNAT family N-acetyltransferase -
VAB027_RS03765 795708..795956 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VAB027_RS03770 795946..796236 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VAB027_RS20335 796254..796364 - 111 WP_082798255.1 DUF3265 domain-containing protein -
VAB027_RS03775 796361..796678 - 318 WP_001232701.1 HigA family addiction module antidote protein -
VAB027_RS03780 796689..796976 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
VAB027_RS03785 797328..797536 - 209 Protein_732 DUF3709 domain-containing protein -
VAB027_RS20155 797833..798465 - 633 WP_046126205.1 hypothetical protein -
VAB027_RS19335 798718..798999 - 282 WP_080341684.1 DUF1289 domain-containing protein -
VAB027_RS20245 798948..799061 - 114 WP_080341690.1 acetyltransferase -
VAB027_RS03795 799117..799497 - 381 WP_046126206.1 glyoxalase -
VAB027_RS03800 799640..799915 - 276 WP_000436062.1 hypothetical protein -
VAB027_RS19350 800197..800433 - 237 WP_080341691.1 DUF3709 domain-containing protein -
VAB027_RS03805 800715..801050 - 336 WP_046126207.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 737949..818855 80906
- inside Integron - - 741722..820081 78359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T52887 WP_000221352.1 NZ_CP010812:795946-796236 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T52887 NZ_CP010812:795946-796236 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAATTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAATTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTATCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTTGTTACAGTTTTAGCTGTTGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT52887 WP_000213183.1 NZ_CP010812:795708-795956 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT52887 NZ_CP010812:795708-795956 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAACTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References