Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 790900..791684 Replicon chromosome
Accession NZ_CP010812
Organism Vibrio cholerae strain 10432-62

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag VAB027_RS03735 Protein ID WP_001114075.1
Coordinates 791415..791684 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag VAB027_RS03730 Protein ID WP_000921691.1
Coordinates 790900..791421 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VAB027_RS03700 785925..786929 - 1005 WP_046126200.1 LD-carboxypeptidase -
VAB027_RS03705 787233..788153 + 921 WP_001896359.1 IS5-like element ISVch8 family transposase -
VAB027_RS03710 788131..788655 - 525 WP_142741359.1 hypothetical protein -
VAB027_RS03715 788803..789540 - 738 WP_046126202.1 hypothetical protein -
VAB027_RS03720 789683..790031 - 349 Protein_717 GrpB family protein -
VAB027_RS03725 790294..790749 - 456 WP_000432865.1 hypothetical protein -
VAB027_RS03730 790900..791421 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
VAB027_RS03735 791415..791684 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
VAB027_RS20240 791936..792031 - 96 WP_001907607.1 DUF645 family protein -
VAB027_RS03740 792442..792720 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VAB027_RS03745 792713..792982 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
VAB027_RS20150 793578..794003 - 426 WP_052724878.1 hypothetical protein -
VAB027_RS03755 794150..794848 - 699 WP_046126203.1 HAD family phosphatase -
VAB027_RS03760 794939..795496 - 558 WP_046126204.1 GNAT family N-acetyltransferase -
VAB027_RS03765 795708..795956 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VAB027_RS03770 795946..796236 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
VAB027_RS20335 796254..796364 - 111 WP_082798255.1 DUF3265 domain-containing protein -
VAB027_RS03775 796361..796678 - 318 WP_001232701.1 HigA family addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 737949..818855 80906
- flank IS/Tn - - 787233..788153 920
- inside Integron - - 741722..820081 78359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T52885 WP_001114075.1 NZ_CP010812:c791684-791415 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T52885 NZ_CP010812:c791684-791415 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT52885 WP_000921691.1 NZ_CP010812:c791421-790900 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT52885 NZ_CP010812:c791421-790900 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCAATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGGACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References