Detailed information of TA system TA052882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 772057..772604
• Replicon: chromosome
• Accession: NZ_CP010812
• Organism: Vibrio cholerae strain 10432-62

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VAB027_RS03580
• Protein ID: WP_046126188.1
• Coordinates: 772057..772359 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: VAB027_RS03585
• Protein ID: WP_046126189.1
• Coordinates: 772347..772604 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAB027_RS03530	767402..767581	-	180	WP_162484547.1	DUF645 family protein	-
VAB027_RS03540	767973..768215	+	243	WP_000557291.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VAB027_RS03545	768234..768551	+	318	WP_046126185.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VAB027_RS20140	768687..768971	-	285	WP_046126186.1	HEAT repeat domain-containing protein	-
VAB027_RS03555	769196..769582	-	387	WP_001015864.1	NUDIX hydrolase	-
VAB027_RS03560	769748..770086	-	339	WP_046127316.1	hypothetical protein	-
VAB027_RS03565	770306..770548	+	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
VAB027_RS03570	770545..770844	+	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VAB027_RS03575	770967..771881	-	915	WP_046126187.1	hypothetical protein	-
VAB027_RS03580	772057..772359	-	303	WP_046126188.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VAB027_RS03585	772347..772604	-	258	WP_046126189.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VAB027_RS03590	772795..773271	-	477	WP_080341680.1	hypothetical protein	-
VAB027_RS03595	773444..773680	+	237	WP_046126190.1	RNA-binding protein	-
VAB027_RS03600	773866..774279	-	414	WP_046126191.1	VOC family protein	-
VAB027_RS03605	775028..775549	-	522	WP_080341682.1	hypothetical protein	-
VAB027_RS03610	775705..776100	-	396	WP_032473749.1	DUF3465 domain-containing protein	-
VAB027_RS03615	776708..777316	-	609	WP_046126193.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	737949..818855	80906
	-	inside	Integron	-	-	741722..820081	78359

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.61 Da
• Isoelectric Point: 5.1972

>T52882 WP_046126188.1 NZ_CP010812:c772359-772057 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T52882 NZ_CP010812:c772359-772057 [Vibrio cholerae]
ATGGCTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCCGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAGCACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9575.09 Da
• Isoelectric Point: 8.5563

>AT52882 WP_046126189.1 NZ_CP010812:c772604-772347 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKGPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT52882 NZ_CP010812:c772604-772347 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGGGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAA