Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 770306..770844 | Replicon | chromosome |
| Accession | NZ_CP010812 | ||
| Organism | Vibrio cholerae strain 10432-62 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | VAB027_RS03570 | Protein ID | WP_000802136.1 |
| Coordinates | 770545..770844 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | VAB027_RS03565 | Protein ID | WP_001107719.1 |
| Coordinates | 770306..770548 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAB027_RS03520 | 765646..766128 | - | 483 | WP_046126181.1 | GNAT family N-acetyltransferase | - |
| VAB027_RS03525 | 766273..766650 | - | 378 | WP_046126182.1 | hypothetical protein | - |
| VAB027_RS19255 | 766866..767042 | - | 177 | Protein_678 | DUF645 family protein | - |
| VAB027_RS03530 | 767402..767581 | - | 180 | WP_162484547.1 | DUF645 family protein | - |
| VAB027_RS03540 | 767973..768215 | + | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VAB027_RS03545 | 768234..768551 | + | 318 | WP_046126185.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VAB027_RS20140 | 768687..768971 | - | 285 | WP_046126186.1 | HEAT repeat domain-containing protein | - |
| VAB027_RS03555 | 769196..769582 | - | 387 | WP_001015864.1 | NUDIX hydrolase | - |
| VAB027_RS03560 | 769748..770086 | - | 339 | WP_046127316.1 | hypothetical protein | - |
| VAB027_RS03565 | 770306..770548 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| VAB027_RS03570 | 770545..770844 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VAB027_RS03575 | 770967..771881 | - | 915 | WP_046126187.1 | hypothetical protein | - |
| VAB027_RS03580 | 772057..772359 | - | 303 | WP_046126188.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VAB027_RS03585 | 772347..772604 | - | 258 | WP_046126189.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VAB027_RS03590 | 772795..773271 | - | 477 | WP_080341680.1 | hypothetical protein | - |
| VAB027_RS03595 | 773444..773680 | + | 237 | WP_046126190.1 | RNA-binding protein | - |
| VAB027_RS03600 | 773866..774279 | - | 414 | WP_046126191.1 | VOC family protein | - |
| VAB027_RS03605 | 775028..775549 | - | 522 | WP_080341682.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 737949..818855 | 80906 | |
| - | inside | Integron | - | - | 741722..820081 | 78359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T52881 WP_000802136.1 NZ_CP010812:770545-770844 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T52881 NZ_CP010812:770545-770844 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT52881 WP_001107719.1 NZ_CP010812:770306-770548 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT52881 NZ_CP010812:770306-770548 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|