Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 758056..758627 | Replicon | chromosome |
| Accession | NZ_CP010812 | ||
| Organism | Vibrio cholerae strain 10432-62 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | VAB027_RS03455 | Protein ID | WP_046126173.1 |
| Coordinates | 758056..758457 (-) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A544N0N8 |
| Locus tag | VAB027_RS03460 | Protein ID | WP_046127315.1 |
| Coordinates | 758457..758627 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAB027_RS20230 | 753367..753474 | - | 108 | WP_080341671.1 | acetyltransferase | - |
| VAB027_RS03425 | 753554..753817 | - | 264 | WP_000098716.1 | Txe/YoeB family addiction module toxin | - |
| VAB027_RS03430 | 753810..754064 | - | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| VAB027_RS03435 | 754274..754756 | - | 483 | WP_001900268.1 | hypothetical protein | - |
| VAB027_RS03440 | 754797..755819 | - | 1023 | WP_046126171.1 | hypothetical protein | - |
| VAB027_RS03445 | 756053..756466 | - | 414 | WP_046126172.1 | VOC family protein | - |
| VAB027_RS19210 | 757243..757479 | - | 237 | WP_080007264.1 | DUF3709 domain-containing protein | - |
| VAB027_RS03450 | 757581..757916 | - | 336 | WP_019829648.1 | hypothetical protein | - |
| VAB027_RS03455 | 758056..758457 | - | 402 | WP_046126173.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| VAB027_RS03460 | 758457..758627 | - | 171 | WP_046127315.1 | hypothetical protein | Antitoxin |
| VAB027_RS03465 | 758818..759231 | - | 414 | Protein_663 | hypothetical protein | - |
| VAB027_RS03470 | 759311..760231 | + | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
| VAB027_RS03475 | 760240..760434 | - | 195 | WP_046126175.1 | hypothetical protein | - |
| VAB027_RS20235 | 760484..760570 | - | 87 | WP_167335580.1 | acetyltransferase | - |
| VAB027_RS03480 | 760627..761130 | - | 504 | WP_046126176.1 | DinB family protein | - |
| VAB027_RS03485 | 761358..761528 | - | 171 | WP_032473200.1 | DUF645 family protein | - |
| VAB027_RS03490 | 761857..762093 | - | 237 | WP_046126177.1 | hypothetical protein | - |
| VAB027_RS03495 | 762348..762743 | - | 396 | WP_046126178.1 | DUF3465 domain-containing protein | - |
| VAB027_RS20330 | 762758..762841 | - | 84 | WP_200894332.1 | iron transporter | - |
| VAB027_RS03500 | 762918..763331 | - | 414 | WP_000451552.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 737949..818855 | 80906 | |
| - | flank | IS/Tn | - | - | 759311..760231 | 920 | |
| - | inside | Integron | - | - | 741722..820081 | 78359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14656.80 Da Isoelectric Point: 4.0585
>T52879 WP_046126173.1 NZ_CP010812:c758457-758056 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENYLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENYLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T52879 NZ_CP010812:c758457-758056 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACTATTTGCTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACTATTTGCTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6317.38 Da Isoelectric Point: 10.7274
>AT52879 WP_046127315.1 NZ_CP010812:c758627-758457 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDTGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDTGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT52879 NZ_CP010812:c758627-758457 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATACTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATACTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|