Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 745768..746327 | Replicon | chromosome |
| Accession | NZ_CP010812 | ||
| Organism | Vibrio cholerae strain 10432-62 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | VAB027_RS03370 | Protein ID | WP_000578471.1 |
| Coordinates | 746049..746327 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | VAB027_RS03365 | Protein ID | WP_000381183.1 |
| Coordinates | 745768..746052 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAB027_RS03330 | 740793..741713 | + | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
| VAB027_RS03340 | 742130..743134 | - | 1005 | WP_046126167.1 | LD-carboxypeptidase | - |
| VAB027_RS03345 | 743302..743589 | - | 288 | WP_017049660.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VAB027_RS03350 | 743586..743867 | - | 282 | WP_000086650.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VAB027_RS03355 | 744095..744523 | - | 429 | WP_000074666.1 | hypothetical protein | - |
| VAB027_RS03360 | 744507..745439 | - | 933 | WP_046126168.1 | hypothetical protein | - |
| VAB027_RS03365 | 745768..746052 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| VAB027_RS03370 | 746049..746327 | + | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| VAB027_RS03375 | 746467..747321 | - | 855 | WP_142741583.1 | aminoglycoside phosphotransferase family protein | - |
| VAB027_RS03380 | 747378..748040 | - | 663 | WP_076008610.1 | Vat family streptogramin A O-acetyltransferase | - |
| VAB027_RS03385 | 748173..748730 | - | 558 | Protein_644 | nucleotidyltransferase domain-containing protein | - |
| VAB027_RS03390 | 749098..749343 | + | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| VAB027_RS03395 | 749343..749660 | + | 318 | WP_000077272.1 | CcdB family protein | - |
| VAB027_RS20325 | 749601..749720 | - | 120 | WP_114780049.1 | acetyltransferase | - |
| VAB027_RS03400 | 749777..750274 | - | 498 | WP_046126169.1 | GNAT family N-acetyltransferase | - |
| VAB027_RS03405 | 750477..750659 | - | 183 | WP_009355233.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 737949..818855 | 80906 | |
| - | inside | Integron | - | - | 741722..820081 | 78359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T52876 WP_000578471.1 NZ_CP010812:746049-746327 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T52876 NZ_CP010812:746049-746327 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT52876 WP_000381183.1 NZ_CP010812:745768-746052 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT52876 NZ_CP010812:745768-746052 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTGGCTGAGCAACAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTGGCTGAGCAACAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |