Detailed information of TA system TA052875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 743302..743867
• Replicon: chromosome
• Accession: NZ_CP010812
• Organism: Vibrio cholerae strain 10432-62

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0F2IXR1
• Locus tag: VAB027_RS03345
• Protein ID: WP_017049660.1
• Coordinates: 743302..743589 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W9USL4
• Locus tag: VAB027_RS03350
• Protein ID: WP_000086650.1
• Coordinates: 743586..743867 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAB027_RS03320	738970..739527	+	558	WP_046126164.1	hypothetical protein	-
VAB027_RS19155	739584..739697	+	114	WP_080341667.1	acetyltransferase	-
VAB027_RS19160	739646..739927	+	282	WP_080284439.1	DUF1289 domain-containing protein	-
VAB027_RS03330	740793..741713	+	921	WP_001896359.1	IS5-like element ISVch8 family transposase	-
VAB027_RS03340	742130..743134	-	1005	WP_046126167.1	LD-carboxypeptidase	-
VAB027_RS03345	743302..743589	-	288	WP_017049660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VAB027_RS03350	743586..743867	-	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VAB027_RS03355	744095..744523	-	429	WP_000074666.1	hypothetical protein	-
VAB027_RS03360	744507..745439	-	933	WP_046126168.1	hypothetical protein	-
VAB027_RS03365	745768..746052	+	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
VAB027_RS03370	746049..746327	+	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
VAB027_RS03375	746467..747321	-	855	WP_142741583.1	aminoglycoside phosphotransferase family protein	-
VAB027_RS03380	747378..748040	-	663	WP_076008610.1	Vat family streptogramin A O-acetyltransferase	-
VAB027_RS03385	748173..748730	-	558	Protein_644	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	737949..818855	80906
	-	inside	Integron	-	-	741722..820081	78359

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10929.71 Da
• Isoelectric Point: 5.6023

>T52875 WP_017049660.1 NZ_CP010812:c743589-743302 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T52875 NZ_CP010812:c743589-743302 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCTTCAGC
TGCAGAAAAGTGGGTGAATGATGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGCCATTACCGCATTATTTATAGTTTGGGCCTCGAAATACGAGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.90 Da
• Isoelectric Point: 5.1548

>AT52875 WP_000086650.1 NZ_CP010812:c743867-743586 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT52875 NZ_CP010812:c743867-743586 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAATATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTGTCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA

Structures

Toxin

• AlphaFold DB: A0A0F2IXR1

Antitoxin

• AlphaFold DB: W9USL4