Detailed information of TA system TA052873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2745437..2745984
• Replicon: chromosome
• Accession: NZ_CP010811
• Organism: Vibrio cholerae strain 1154-74

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VAA049_RS12515
• Protein ID: WP_000818171.1
• Coordinates: 2745437..2745739 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: VAA049_RS12520
• Protein ID: WP_000861987.1
• Coordinates: 2745727..2745984 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAA049_RS12485	2740635..2741060	-	426	WP_002023413.1	hypothetical protein	-
VAA049_RS12490	2741295..2741801	-	507	WP_002053776.1	GNAT family N-acetyltransferase	-
VAA049_RS12495	2741939..2742538	-	600	WP_046122430.1	glutathione S-transferase N-terminal domain-containing protein	-
VAA049_RS12500	2742683..2743147	-	465	WP_046122027.1	ASCH domain-containing protein	-
VAA049_RS12505	2743401..2743661	-	261	WP_046122028.1	DUF3709 domain-containing protein	-
VAA049_RS12510	2743944..2744720	-	777	WP_046122029.1	FRG domain-containing protein	-
VAA049_RS19105	2744942..2744980	-	39	WP_110168446.1	hypothetical protein	-
VAA049_RS18725	2744999..2745124	-	126	WP_080342539.1	DUF645 family protein	-
VAA049_RS12515	2745437..2745739	-	303	WP_000818171.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VAA049_RS12520	2745727..2745984	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VAA049_RS12525	2746175..2746561	-	387	WP_000703159.1	VOC family protein	-
VAA049_RS12530	2746769..2746950	-	182	Protein_2422	DUF645 family protein	-
VAA049_RS18740	2747306..2747487	-	182	Protein_2423	DUF645 family protein	-
VAA049_RS18745	2747659..2747781	-	123	WP_080342637.1	DUF3265 domain-containing protein	-
VAA049_RS12540	2747778..2748275	-	498	WP_046122031.1	DUF2867 domain-containing protein	-
VAA049_RS12545	2748513..2749472	+	960	WP_046122032.1	IS30 family transposase	-
VAA049_RS12550	2749759..2750568	-	810	WP_046122033.1	DUF4393 domain-containing protein	-
VAA049_RS19115	2750831..2750974	-	144	WP_075042602.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	2722425..2769924	47499

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.57 Da
• Isoelectric Point: 4.8838

>T52873 WP_000818171.1 NZ_CP010811:c2745739-2745437 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T52873 NZ_CP010811:c2745739-2745437 [Vibrio cholerae]
ATGGCTGAAATAGTTTGGACGGAACCAGCTCTATCCGATCTAAATGATATTGCTGAATACATAGCGCTTGAAAATGTCGT
AGCTGCTAAACAACTGGTGCAAACTATTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGACGCATTCCAC
CAGAACTAGAGCACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGCCGTGTTTTCTACAAGTATGATGATGCAAATGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT52873 WP_000861987.1 NZ_CP010811:c2745984-2745727 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT52873 NZ_CP010811:c2745984-2745727 [Vibrio cholerae]
ATGAAAGTAGAACTTGTAACTTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACTAAAGAGCCAGT
ATTGATAACTGAGCATGGAAAGCCGTCAGCTTATCTTATTGATGTAGATGATTATGAATTTATGCAAAATCGTTTAGCAA
TCCTCGAAGGAATTGCTCGTGGTGAGCGAGCTCTAGCGGATGGCAAAGTAGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9