Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2730831..2731390 | Replicon | chromosome |
| Accession | NZ_CP010811 | ||
| Organism | Vibrio cholerae strain 1154-74 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0N9E9 |
| Locus tag | VAA049_RS12420 | Protein ID | WP_000578475.1 |
| Coordinates | 2731112..2731390 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | VAA049_RS12415 | Protein ID | WP_000381184.1 |
| Coordinates | 2730831..2731115 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAA049_RS12380 | 2726003..2726521 | - | 519 | WP_000699012.1 | GNAT family N-acetyltransferase | - |
| VAA049_RS12385 | 2726677..2726964 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VAA049_RS12390 | 2726961..2727242 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VAA049_RS12395 | 2727502..2727684 | - | 183 | WP_002044921.1 | DUF645 family protein | - |
| VAA049_RS12400 | 2727978..2728370 | - | 393 | WP_144407500.1 | nuclear transport factor 2 family protein | - |
| VAA049_RS19425 | 2728347..2728451 | - | 105 | Protein_2393 | acetyltransferase | - |
| VAA049_RS18700 | 2728639..2728794 | - | 156 | WP_187372684.1 | DUF3709 domain-containing protein | - |
| VAA049_RS12405 | 2729074..2730033 | + | 960 | WP_046121687.1 | IS30 family transposase | - |
| VAA049_RS12410 | 2730056..2730634 | - | 579 | WP_001020574.1 | DJ-1/PfpI family protein | - |
| VAA049_RS12415 | 2730831..2731115 | + | 285 | WP_000381184.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| VAA049_RS12420 | 2731112..2731390 | + | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| VAA049_RS12425 | 2731538..2731987 | - | 450 | WP_046122021.1 | GyrI-like domain-containing protein | - |
| VAA049_RS12430 | 2732123..2732611 | - | 489 | WP_000424242.1 | hypothetical protein | - |
| VAA049_RS12435 | 2732754..2733758 | - | 1005 | WP_046122022.1 | LD-carboxypeptidase | - |
| VAA049_RS12440 | 2733966..2734391 | - | 426 | WP_032475742.1 | hypothetical protein | - |
| VAA049_RS12445 | 2734662..2735096 | - | 435 | WP_000256034.1 | GNAT family N-acetyltransferase | - |
| VAA049_RS12450 | 2735253..2735666 | - | 414 | WP_000451550.1 | GNAT family N-acetyltransferase | - |
| VAA049_RS12455 | 2735825..2736334 | - | 510 | WP_046122023.1 | ATPase AAA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 2722425..2769924 | 47499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10824.53 Da Isoelectric Point: 4.6794
>T52872 WP_000578475.1 NZ_CP010811:2731112-2731390 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T52872 NZ_CP010811:2731112-2731390 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTCCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTCCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10874.18 Da Isoelectric Point: 7.2810
>AT52872 WP_000381184.1 NZ_CP010811:2730831-2731115 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIATAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIATAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT52872 NZ_CP010811:2730831-2731115 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCACAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCACAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|