Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 2726677..2727242 | Replicon | chromosome |
| Accession | NZ_CP010811 | ||
| Organism | Vibrio cholerae strain 1154-74 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | VAA049_RS12385 | Protein ID | WP_000869999.1 |
| Coordinates | 2726677..2726964 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | VAA049_RS12390 | Protein ID | WP_000086649.1 |
| Coordinates | 2726961..2727242 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAA049_RS12355 | 2722425..2723465 | + | 1041 | WP_046121496.1 | IS481 family transposase | - |
| VAA049_RS12360 | 2723717..2724256 | - | 540 | WP_001898634.1 | phosphoglycerate mutase family protein | - |
| VAA049_RS12365 | 2724428..2724724 | - | 297 | WP_000617997.1 | Dabb family protein | - |
| VAA049_RS12370 | 2724949..2725401 | + | 453 | WP_000024294.1 | DUF2384 domain-containing protein | - |
| VAA049_RS12375 | 2725401..2725871 | + | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| VAA049_RS12380 | 2726003..2726521 | - | 519 | WP_000699012.1 | GNAT family N-acetyltransferase | - |
| VAA049_RS12385 | 2726677..2726964 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VAA049_RS12390 | 2726961..2727242 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VAA049_RS12395 | 2727502..2727684 | - | 183 | WP_002044921.1 | DUF645 family protein | - |
| VAA049_RS12400 | 2727978..2728370 | - | 393 | WP_144407500.1 | nuclear transport factor 2 family protein | - |
| VAA049_RS19425 | 2728347..2728451 | - | 105 | Protein_2393 | acetyltransferase | - |
| VAA049_RS18700 | 2728639..2728794 | - | 156 | WP_187372684.1 | DUF3709 domain-containing protein | - |
| VAA049_RS12405 | 2729074..2730033 | + | 960 | WP_046121687.1 | IS30 family transposase | - |
| VAA049_RS12410 | 2730056..2730634 | - | 579 | WP_001020574.1 | DJ-1/PfpI family protein | - |
| VAA049_RS12415 | 2730831..2731115 | + | 285 | WP_000381184.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| VAA049_RS12420 | 2731112..2731390 | + | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| VAA049_RS12425 | 2731538..2731987 | - | 450 | WP_046122021.1 | GyrI-like domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2722425..2723465 | 1040 | |
| - | inside | Integron | - | - | 2722425..2769924 | 47499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T52871 WP_000869999.1 NZ_CP010811:c2726964-2726677 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T52871 NZ_CP010811:c2726964-2726677 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATCATTTTCGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATCATTTTCGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT52871 WP_000086649.1 NZ_CP010811:c2727242-2726961 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT52871 NZ_CP010811:c2727242-2726961 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |