Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1740624..1741134 | Replicon | chromosome |
| Accession | NZ_CP010811 | ||
| Organism | Vibrio cholerae strain 1154-74 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | A0A0F2IA90 |
| Locus tag | VAA049_RS07960 | Protein ID | WP_000098716.1 |
| Coordinates | 1740624..1740887 (-) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7Y3QZ95 |
| Locus tag | VAA049_RS07965 | Protein ID | WP_001223794.1 |
| Coordinates | 1740880..1741134 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VAA049_RS07930 | 1735694..1736653 | + | 960 | WP_046121687.1 | IS30 family transposase | - |
| VAA049_RS18995 | 1736684..1737238 | - | 555 | WP_071187841.1 | DUF4875 domain-containing protein | - |
| VAA049_RS07940 | 1737391..1737750 | - | 360 | Protein_1520 | VOC family protein | - |
| VAA049_RS07945 | 1737914..1738309 | - | 396 | WP_000870860.1 | DUF3465 domain-containing protein | - |
| VAA049_RS18490 | 1738344..1738502 | - | 159 | WP_080342440.1 | DUF3265 domain-containing protein | - |
| VAA049_RS07950 | 1739272..1739667 | - | 396 | WP_032479100.1 | DUF3465 domain-containing protein | - |
| VAA049_RS19230 | 1739835..1740572 | - | 738 | WP_158507619.1 | hypothetical protein | - |
| VAA049_RS07960 | 1740624..1740887 | - | 264 | WP_000098716.1 | Txe/YoeB family addiction module toxin | Toxin |
| VAA049_RS07965 | 1740880..1741134 | - | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| VAA049_RS07970 | 1741404..1741585 | - | 182 | Protein_1527 | DUF645 family protein | - |
| VAA049_RS07985 | 1741990..1742271 | - | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| VAA049_RS18510 | 1742220..1742333 | - | 114 | WP_080342443.1 | acetyltransferase | - |
| VAA049_RS07990 | 1742390..1742746 | - | 357 | WP_046121691.1 | hypothetical protein | - |
| VAA049_RS07995 | 1742886..1743311 | - | 426 | WP_046121692.1 | GNAT family N-acetyltransferase | - |
| VAA049_RS18515 | 1743337..1743447 | - | 111 | WP_080342631.1 | DUF3265 domain-containing protein | - |
| VAA049_RS08000 | 1743444..1743902 | - | 459 | WP_046121693.1 | hypothetical protein | - |
| VAA049_RS08005 | 1744057..1744533 | - | 477 | WP_046121694.1 | GNAT family N-acetyltransferase | - |
| VAA049_RS19015 | 1744499..1744672 | - | 174 | Protein_1535 | DUF3265 domain-containing protein | - |
| VAA049_RS08010 | 1744669..1745088 | - | 420 | WP_041051853.1 | hypothetical protein | - |
| VAA049_RS08015 | 1745289..1745471 | - | 183 | WP_002044921.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1721457..1758901 | 37444 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10401.72 Da Isoelectric Point: 7.9816
>T52870 WP_000098716.1 NZ_CP010811:c1740887-1740624 [Vibrio cholerae]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY
Download Length: 264 bp
>T52870 NZ_CP010811:c1740887-1740624 [Vibrio cholerae]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAGGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGGTT
ATTTCGTGTCGCTACCATTATTGA
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAGGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGGTT
ATTTCGTGTCGCTACCATTATTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9437.64 Da Isoelectric Point: 5.0481
>AT52870 WP_001223794.1 NZ_CP010811:c1741134-1740880 [Vibrio cholerae]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE
Download Length: 255 bp
>AT52870 NZ_CP010811:c1741134-1740880 [Vibrio cholerae]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCTGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAATGCTGAACATCTAAACCGTTCAATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCTGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAATGCTGAACATCTAAACCGTTCAATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F2IA90 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y3QZ95 |