Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 2453102..2453678 Replicon chromosome
Accession NZ_CP010802
Organism Desulfuromonas soudanensis strain WTL

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M4D7D5
Locus tag DSOUD_RS11050 Protein ID WP_053551067.1
Coordinates 2453322..2453678 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M4D269
Locus tag DSOUD_RS11045 Protein ID WP_053551066.1
Coordinates 2453102..2453332 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSOUD_RS11030 2449546..2450520 - 975 WP_053552369.1 GDP-L-fucose synthase -
DSOUD_RS11035 2450572..2451702 - 1131 WP_053551064.1 GDP-mannose 4,6-dehydratase -
DSOUD_RS11040 2451994..2452341 - 348 WP_053551065.1 helix-turn-helix domain-containing protein -
DSOUD_RS18495 2452492..2452743 - 252 WP_157671846.1 hypothetical protein -
DSOUD_RS11045 2453102..2453332 + 231 WP_053551066.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DSOUD_RS11050 2453322..2453678 + 357 WP_053551067.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DSOUD_RS11055 2453839..2454189 - 351 WP_053551068.1 DUF86 domain-containing protein -
DSOUD_RS11060 2454182..2454475 - 294 WP_082351226.1 nucleotidyltransferase family protein -
DSOUD_RS11065 2454577..2455500 - 924 Protein_2226 transposase -
DSOUD_RS11070 2455595..2455873 + 279 WP_198300308.1 type II toxin-antitoxin system PemK/MazF family toxin -
DSOUD_RS11075 2456023..2456334 - 312 WP_053551072.1 helix-turn-helix domain-containing protein -
DSOUD_RS11080 2456321..2456659 - 339 WP_053551073.1 transcriptional regulator -
DSOUD_RS18170 2457022..2457126 - 105 Protein_2230 transposase -
DSOUD_RS11085 2457244..2457540 + 297 WP_053551074.1 nucleotidyltransferase family protein -
DSOUD_RS11090 2457530..2457880 + 351 WP_053551075.1 DUF86 domain-containing protein -
DSOUD_RS18175 2458312..2458416 - 105 Protein_2233 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-110)

Antitoxin

PrlF antitoxin

(6-45)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12997.10 Da        Isoelectric Point: 6.9787

>T52869 WP_053551067.1 NZ_CP010802:2453322-2453678 [Desulfuromonas soudanensis]
VSYNAFDVVVVPFPFTDKATTKHRPALILSDAQTFNQQVGQAVMAMITSAKNSDWPLDIEIRDLDSAGLPSPSMIRMKLF
TLDEKLIIRKTGELAGPDQAKVIAALRQLLPCLSARQE

Download         Length: 357 bp

>T52869 NZ_CP010802:2453322-2453678 [Desulfuromonas soudanensis]
GTGAGCTATAATGCCTTCGATGTCGTCGTTGTCCCCTTTCCCTTTACGGACAAAGCTACAACCAAGCACAGACCGGCATT
GATTCTCTCCGATGCTCAGACCTTTAATCAGCAGGTTGGCCAGGCCGTCATGGCGATGATTACAAGTGCCAAAAATTCGG
ATTGGCCGCTCGATATTGAGATCCGGGATCTGGATTCCGCCGGCCTCCCCTCACCTTCGATGATTCGGATGAAACTGTTC
ACCCTGGACGAAAAGTTGATTATCAGAAAAACCGGGGAACTCGCCGGCCCGGATCAGGCCAAAGTCATAGCGGCGCTGCG
CCAGCTGCTTCCCTGCCTTTCGGCCCGGCAAGAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8534.64 Da        Isoelectric Point: 4.4678

>AT52869 WP_053551066.1 NZ_CP010802:2453102-2453332 [Desulfuromonas soudanensis]
MTTATSKITSKYQATIPEPVRKVLHLKAGDAIAFDIEDDQIRIRKARPLDLVFAEALEGTLTEWDSAADEEAYREL

Download         Length: 231 bp

>AT52869 NZ_CP010802:2453102-2453332 [Desulfuromonas soudanensis]
ATGACAACTGCGACGAGTAAAATCACATCCAAATATCAAGCGACCATTCCGGAACCGGTTCGAAAAGTCCTGCACTTGAA
AGCTGGGGACGCCATTGCCTTTGACATCGAAGACGACCAAATCCGGATCAGGAAGGCAAGGCCCCTGGATCTGGTCTTTG
CGGAGGCTCTTGAAGGGACGCTGACCGAATGGGACTCGGCCGCCGATGAAGAGGCGTATCGTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4D7D5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4D269

References